Immune-based strategies for mood disorders: facts and challenges.
Immune-based strategies for mood disorders: facts and challenges.
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DOI：
10.1080/14737175.2018.1407242
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发表时间：
2018-03
影响因子：
4.3
通讯作者：
Teixeira AL
中科院分区：
文献类型：
--
作者：
Colpo GD;Leboyer M;Dantzer R;Trivedi MH;Teixeira AL
炎症似乎在心境障碍的病理生理学中起作用，包括重性抑郁症（MDD）和双相情感障碍（BD）。在过去的几年中，一些研究表明，情绪障碍患者的炎症和/或免疫标志物水平增加。因此，免疫系统已成为开发情绪障碍的生物标志物和治疗剂的目标。在这里，我们回顾了情绪障碍中低度炎症的证据，以及评估治疗这些疾病的免疫策略的研究。非甾体抗炎药、多不饱和酸、N-乙酰半胱氨酸、抗细胞因子、体力活动和益生菌的临床试验在MDD和BD患者的抗抑郁疗效方面提供了有希望的结果。关于干细胞，迄今为止仅进行了动物模型研究，并获得了有趣的临床前结果。由于结果的初步性质，大多数临床研究需要在更大的临床环境中重复和/或确认，包括情绪障碍的高度异质性病理生理学。
Inflammation seems to play a role in the pathophysiology of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). In the last years several studies have shown increased levels of inflammatory and/or immune markers in patients with mood disorders. Accordingly, the immune system has become a target of interest for the development of biomarkers and therapeutics for mood disorders. Here, we review the evidence showing low-grade inflammation in mood disorders and the studies evaluating immune-based strategies for the treatment of these conditions. Clinical trials with non-steroidal anti-inflammatory drugs, polyunsaturated acids, N-acetylcysteine, anti-cytokines, physical activity and probiotics have provided promising results in terms of antidepressant efficacy in patients with MDD and BD. Regarding stem cells, only studies with animal models have been performed so far with interesting pre-clinical results. Due to the preliminary nature of the results, most of the clinical studies need to be replicated and/or confirmed in larger clinical settings, embracing the highly heterogeneous pathophysiology of mood disorders.
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