Evolution of a central neural circuit underlies Drosophila mate preferences.

Evolution of a central neural circuit underlies Drosophila mate preferences.
复制标题

DOI:
10.1038/s41586-018-0322-9
复制
发表时间:
2018-07
期刊:
影响因子:
64.8
通讯作者:
Ruta V
Ruta V
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Seeholzer LF;Seppo M;Stern DL;Ruta V

文献摘要

参考文献

被引文献

相似文献

求偶仪式有助于加强近亲物种之间的生殖障碍。果蝇(Drosophila melanogaster)和D. simulans表现出生殖隔离,部分原因是D.黑腹果蝇雌性产生7,11-二十七碳二烯(7,11-HD),这是一种促进果蝇求偶的信息素。melanogaster雄性,但抑制D. simulans male.在这里,我们比较信息素加工途径在D。黑腹果蝇D. simulans雄性来定义这些姐妹物种如何赋予7,11-HD相反的行为价,以构成物种歧视的基础。我们发现,这两个物种的男性检测7,11-HD使用同源的外周感觉神经元,但这个信号是差异传播到P1神经元,控制求偶行为。对求偶促进神经元的兴奋和抑制平衡的改变转化为D。melanogaster转化为抑制线索。simulans。我们的研究结果揭示了物种特异性信息素反应如何从外围检测机制的保护和中央电路的多样化中产生,并说明了神经电路中的灵活节点如何有助于行为进化。
Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and D. simulans exhibit reproductive isolation due, in part, to the fact that D. melanogaster females produce 7,11-heptacosadiene (7,11-HD), a pheromone that promotes courtship in D. melanogaster males but suppresses courtship in D. simulans males. Here we compare pheromone-processing pathways in D. melanogaster and D. simulans males to define how these sister species endow 7,11-HD with the opposite behavioral valence to underlie species discrimination. We show that males of both species detect 7,11-HD using the homologous peripheral sensory neurons but this signal is differentially propagated to the P1 neurons that control courtship behavior. A change in the balance of excitation and inhibition onto courtship-promoting neurons transforms an excitatory pheromonal cue in D. melanogaster into an inhibitory cue in D. simulans. Our results reveal how species-specific pheromone responses can emerge from conservation of peripheral detection mechanisms and diversification of central circuitry and illustrate how flexible nodes in neural circuits can contribute to behavioral evolution.
DOI: 10.1038/nature08495
发表时间: 2009-10-15
期刊: NATURE
影响因子: 64.8
作者:
Billeter, Jean-Christophe;Atallah, Jade;Levine, Joel D.
通讯作者: Levine, Joel D.
DOI: 10.1111/j.1558-5646.1987.tb05798.x
发表时间: 1987-03-01
期刊: EVOLUTION
影响因子: 3.3
作者:
JALLON, JM;DAVID, JR
通讯作者: DAVID, JR
DOI: 10.1163/156853955x00184
发表时间: 1955-01-01
期刊: BEHAVIOR
影响因子: --
作者:
BASTOCK, M.;MANNING, A.
通讯作者: MANNING, A.
DOI: 10.1038/nmeth.2765
发表时间: 2014-03
期刊: NATURE METHODS
影响因子: 48
作者:
Inagaki, Hidehiko K.;Jung, Yonil;Hoopfer, Eric D.;Wong, Allan M.;Mishra, Neeli;Lin, John Y.;Tsien, Roger Y.;Anderson, David J.
通讯作者: Anderson, David J.
DOI: 10.1038/ncomms7457
发表时间: 2015-03-01
影响因子: 16.6
作者:
Kohatsu, Soh;Yamamoto, Daisuke
通讯作者: Yamamoto, Daisuke