Transfer of incentive salience from a first-order alcohol cue to a novel second-order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence.
Transfer of incentive salience from a first-order alcohol cue to a novel second-order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence.
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激励显着性从一阶酒精提示转移到具有酒精使用障碍风险的个体中的新型二阶酒精提示：电生理证据。
DOI：
10.1111/add.15380
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Bartholow BD
中科院分区：
文献类型：
--
作者：
Fleming KA;Cofresí RU;Bartholow BD
In susceptible individuals, cues associated with drug use are theorized to take on incentive-motivational properties, including the ability to reinforce higher-order, drug-related associative learning. This study aimed to test this prediction among people varying in risk for alcohol use disorder. Repeated measures experiment with a measured individual difference variable. University Psychology laboratory in Missouri, USA. One hundred-six young adults (96 contributed complete data) pre-selected to represent the upper and lower quartiles of self-reported sensitivity to alcohol’s acute effects. Participants completed a second-order Pavlovian conditioning paradigm in which an initially neutral visual cue (second-order conditional stimulus; CS2) predicted onset of an olfactory cue (first-order conditional stimulus; CS1). Olfactory cues were isolated from alcoholic beverages, sweets, and non-comestible substances, each presumed to have a natural history of first-order conditioning. Event-related potential responses to the CS2 across its conditioning and extinction, and to the CS1, provided neurophysiological indices of incentive salience (IS). The IS of the alcohol CS1 was higher among participants low in alcohol sensitivity (LS), relative to their higher-sensitivity (HS) peers. The IS of the CS2 paired with the alcohol CS1 increased across the CS2 conditioning phase among LS but not HS participants. Also, LS (but not HS) individuals also experienced increases in alcohol craving following alcohol CS1 exposure, and this change was correlated with increases in the IS of the CS2 paired with the alcohol CS1. Alcoholic beverage odor, a proximal cue for alcohol consumption, reinforced conditioning of neurophysiological responses to a novel cue among LS but not HS individuals, providing the first evidence that the LS phenotype may be associated with differences in the conditioned reinforcing properties of alcohol-related cues. These findings support the idea that the LS phenotype may increase AUD risk via susceptibility to incentive salience sensitization.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
3.7
作者：
Bacigalupo F;Luck SJ
通讯作者：
Luck SJ
影响因子：
6
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
影响因子：
3.4
作者：
Bartholow, Bruce D.;Lust, Sarah A.;Tragesser, Sarah L.
通讯作者：
Tragesser, Sarah L.
影响因子：
10.6
作者：
Dockree, Paul M.;Barnes, Jessica J.;O'Connell, Redmond G.
通讯作者：
O'Connell, Redmond G.