The effect of different intensities of treadmill exercise on cognitive function deficit following a severe controlled cortical impact in rats.
The effect of different intensities of treadmill exercise on cognitive function deficit following a severe controlled cortical impact in rats.
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不同强度的跑步机运动对大鼠严重受控皮质冲击后认知功能缺陷的影响
DOI：
10.3390/ijms141121598
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发表时间：
2013-10-31
影响因子：
5.6
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Shen X;Li A;Zhang Y;Dong X;Shan T;Wu Y;Jia J;Hu Y
运动已被提议用于治疗创伤性脑损伤（TBI）。然而，在严重创伤性脑损伤后的早期阶段，合适的运动强度在很大程度上是未知的。为了比较两种不同的跑步机运动强度对严重创伤性脑损伤早期阶段认知功能的影响，大鼠接受了可控皮质撞击（CCI），并被迫在跑步机上运动14天。结果显示，与对照组相比，低强度运动组的大鼠找到平台的潜伏期更短，在莫里斯水迷宫（MWM）中空间记忆的改善明显更好（p < 0.05）。与对照组大鼠相比，高强度运动组在莫里斯水迷宫中潜伏期更长，空间记忆有轻微改善；然而，这种差异没有统计学意义（p > 0.05）。低强度运动组对侧海马中的脑源性神经营养因子（BDNF）和p - CREB蛋白水平显著升高。我们的研究结果表明，在严重创伤性脑损伤早期阶段，2周的低强度跑步机运动有利于改善认知功能和增加海马体中BDNF的表达。
Exercise has been proposed for the treatment of traumatic brain injury (TBI). However, the proper intensity of exercise in the early phase following a severe TBI is largely unknown. To compare two different treadmill exercise intensities on the cognitive function following a severe TBI in its early phase, rats experienced a controlled cortical impact (CCI) and were forced to treadmill exercise for 14 days. The results revealed that the rats in the low intensity exercise group had a shorter latency to locate a platform and a significantly better improvement in spatial memory in the Morris water maze (MWM) compared to the control group (p < 0.05). The high intensity exercise group showed a longer latency and a mild improvement in spatial memory compared to the control group rats in the MWM; however, this difference was not statistically significant (p > 0.05). The brain-derived neurotrophic factor (BDNF) and p-CREB protein levels in the contralateral hippocampus were increased significantly in the low intensity exercise group. Our results suggest that 2 weeks of low intensity of treadmill exercise is beneficial for improving cognitive function and increasing hippocampal BDNF expression after a severe TBI in its early phase.
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影响因子：
15.1
作者：
Hoffman-Goetz, L.;Spagnuolo, P. A.;Guan, J.
通讯作者：
Guan, J.
DOI：
10.1097/00005768-199709000-00009
发表时间：
1997-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Bruunsgaard, H;Hartkopp, A;Pedersen, BK
通讯作者：
Pedersen, BK
影响因子：
3.3
作者：
Cassilhas, R. C.;Lee, K. S.;de Mello, M. T.
通讯作者：
de Mello, M. T.
影响因子：
3.3
作者：
Griesbach, GS;Hovda, DA;Gomez-Pinilla, F
通讯作者：
Gomez-Pinilla, F
影响因子：
4.2
作者：
Kochanek, OM;Marion, DW;DeKosky, ST
通讯作者：
DeKosky, ST