Role of BC040587 as a predictor of poor outcome in breast cancer.
Role of BC040587 as a predictor of poor outcome in breast cancer.
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DOI：
10.1186/s12935-014-0123-7
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发表时间：
2014
影响因子：
5.8
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Chi Y;Huang S;Yuan L;Liu M;Huang N;Zhou S;Zhou B;Wu J
越来越多的研究集中在新发现的lncRNA的致癌和肿瘤抑制作用。发现3q13.31位点存在一种新的lncRNA BC 040587，其存在频繁的拷贝数改变，与骨肉瘤患者的不良生存相关。然而，它在乳腺癌（BC）中的作用仍然未知。本研究的目的是检测BC 040587在BC中的表达模式，并评估其生物学作用和预测预后的临床意义。通过定量逆转录聚合酶链反应（qRT-PCR）分析了20对BC癌组织和邻近非癌组织（ANCT）中BC 040587的表达，还分析了151个BC组织、9个BC细胞系和1个正常乳腺细胞系中BC 040587的表达。使用Student t检验（双尾）检验组间差异的显著性。分析BC 040587表达与BC临床病理特征的关系。用SPSS软件进行相关性分析。结果表明，BC 040587基因在BC样品和BC细胞系中的表达均较相应的正常对照组下调。BC 040587表达与绝经状态（p = 0.040）和肿瘤分化（p = 0.035）相关。Kaplan-Meier生存曲线表明，低BC 040587表达的BC患者的总生存期（OS）显著较差（p = 0.023）。此外，BC 040587的表达与较差的预后显著相关，并且被证明是乳腺癌的独立预后标志物（p = 0.032）。我们的研究表明，BC 040587可能代表乳腺癌预后的新标志物。我们的研究表明，BC 040587在BC组织和BC细胞系中显著下调。BC 040587可能是乳腺癌预后的新标志物。
Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found to be associated with poor survival of osteosarcoma patients. However, its role in breast cancer (BC) remains unknown. The aim of this study was to examine the expression pattern of BC040587 in BC and to evaluate its biological role and clinical significance in prediction of prognosis. Expression of BC040587 was analyzed in 20 pairs of BC cancer tissues and adjacent noncancerous tissues (ANCT), also in 151 BC tissues, 9 BC cell lines and one normal breast cell line by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Differences between groups were tested for significance using Student’s t-test (two-tailed). Then we analyzed the potential relationship between BC040587 expression and clinic pathological features of BC patients. The correlation was analyzed by SPSS software. It showed that BC040587 expression was down regulated both in BC samples and in BC cell lines compared with corresponding normal control. BC040587 expression was correlated with menopausal status (p = 0.040) and tumor differentiation (p = 0.035). The Kaplan-Meier survival curves indicated that the overall survival (OS) was significantly poor in low BC040587 expression BC patients (p = 0.023). Furthermore, expression of BC040587 was significantly associated with worse prognosis and was shown to be an independent prognostic marker breast cancer (p = 0.032). Our studies indicate that BC040587 may represent a new marker of prognosis in breast cancer. Our studies indicate that BC040587 is significantly down-regulated in BC tissues and BC cell lines. BC040587 may represent a new marker of prognosis in breast cancer.
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