Plasticity of T cell memory responses to viruses.

Plasticity of T cell memory responses to viruses.
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DOI:
10.1016/s1074-7613(03)00356-x
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发表时间:
2004-01
期刊:
影响因子:
32.4
通讯作者:
Welsh RM
Welsh RM
中科院分区:
医学1区
文献类型:
--
作者:
Selin LK;Welsh RM

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Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens and accommodate memory pools to many pathogens in a finite immune system. This is in part accounted for by crossreactive memory T cells, which can be employed in immune responses and mediate protective immunity or life-threatening immunopathology.
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