Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.
Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.
复制标题
DOI：
10.1016/j.ijporl.2020.110518
复制
发表时间：
2021-01
影响因子：
1.5
通讯作者：
Barkmeier-Kraemer JM
中科院分区：
文献类型：
--
作者：
Stevens M;Mayerl CJ;Bond L;German RZ;Barkmeier-Kraemer JM
The purpose of this study was to elucidate the pathophysiology of aspiration in previously studied female infant piglets after a unilateral superior laryngeal nerve (uSLN) lesion. Videofluoroscopic swallow studies (VFSS) were acquired from 15 female piglets ages 2-3 weeks (9 with uSLN lesion and 6 controls). VFSS were analyzed at 30 frames/second sampling rate. Quantitative measures were conducted and compared between groups using published methodologies for VFSS assessment in adult and infant humans. Measures included the: 1) number of lingual-palatal contacts (LPC) (i.e. pre-swallow), 2) total pharyngeal transit time (TPT), 3) offset of swallow (offP), as well as onset of: 4) pharyngeal stage (onP), 5) pharyngoesophageal segment opening (oPES), 6) maximum PES opening (maxPES), 7) airway closure onset (oAC), and 8) maximum airway closure (maxAC). Measures 5-7 were determined relative to onP. Bolus residue was rated by severity (0 (none) to 3 (severe)). A gamma regression was used to compare continuous measures between lesioned and control groups. The number of LPC (p=.006), TPT (p=.023) and timing of maxAC (p=.041) were significantly greater in the uSLN lesion than the control group. Outcomes of this study replicated prior published findings and elucidated that piglets with right uSLN lesions exhibited delayed maxAC. Noteworthy was the use of clinically relevant quantitative videofluoroscopic measures in piglets for comparison to future studies in human pediatric populations.
登录
查看更多内容
影响因子：
2.6
作者：
Ding, Peng;Campbell-Malone, Regina;Holman, Shaina D.;Lukasik, Stacey L.;Fukuhara, Takako;Gierbolini-Norat, Estela M.;Thexton, Allan J.;German, Rebecca Z.
通讯作者：
German, Rebecca Z.
影响因子：
1.7
作者：
Barlow, Steven M.;Estep, Meredith
通讯作者：
Estep, Meredith
影响因子：
2.6
作者：
Ding, Peng;Campbell-Malone, Regina;Holman, Shaina D.;Lukasik, Stacey L.;Thexton, Allan J.;German, Rebecca Z.
通讯作者：
German, Rebecca Z.
影响因子：
4.7
作者：
BENTOVIM, A
通讯作者：
BENTOVIM, A
影响因子：
2.6
作者：
Djugai, S.;Boeger, D.;Guntinas-Lichius, O.
通讯作者：
Guntinas-Lichius, O.