CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents.
CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents.
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DOI：
10.1016/j.psyneuen.2014.02.002
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发表时间：
2014-05
影响因子：
3.7
通讯作者：
Koenen, Karestan C.
中科院分区：
文献类型：
--
作者：
Sumner, Jennifer A.;McLaughlin, Katie A.;Walsh, Kate;Sheridan, Margaret A.;Koenen, Karestan C.
这项研究考察了促肾上腺皮质激素释放激素受体I型(CRHR1)基因的多态(Rs110402)和儿童虐待史--单独和交互作用--对青少年皮质醇反应模式的贡献。对年龄在13-17岁、有儿童性虐待史(n=61)和无虐待史(n=97)的青少年进行了Trier社会压力测试(TSST)。在基线、TSST语音部分开始后15分钟和30分钟评估唾液皮质醇。同时采集唾液样本进行rs110402基因分型。具有一个或多个G等位基因rs110402的青少年，相对于A等位基因纯合子，以及那些遭受虐待的青少年，相对于非暴露青少年，表现出对TSST的钝性皮质醇反应(尽管这些关联接近但没有达到在我们的种族和民族多样性样本中考虑潜在人群结构时的统计学意义水平)。在G等位基因携带者中，也有更强的儿童虐待与皮质醇低反应性相关的趋势，但这种相关性在统计学上没有显著意义。研究结果表明，CRHR1基因变异可能会缓和虐待儿童对HPA轴功能的下游影响，并对理解与早期逆境相关的风险机制进行了讨论。
This study examined the contributions of a polymorphism of the corticotropin-releasing hormone receptor type I (CRHR1)gene (rs110402) and a history of child maltreatment—alone and in interaction—to patterns of cortisol reactivity in adolescents. Adolescents between the age of 13 and 17 years with (n = 61) and without (n = 97) a history of child maltreatment were exposed to the Trier Social Stress Test (TSST). Salivary cortisol was assessed at baseline, and 15 and 30 minutes after the start of the speech portion of the TSST. Saliva samples for genotyping rs110402 also were collected. Adolescents with one or more G alleles of rs110402, relative to A allele homozygotes, and those exposed to maltreatment, relative to non-exposed adolescents, exhibited blunted cortisol reactivity to the TSST (although these associations approached, but did not reach, the level of statistical significance when accounting for underlying population structure in our racially and ethnically diverse sample). There was also a trend for a stronger child maltreatment association with cortisol hypo-reactivity among G allele carriers, but this association was not statistically significant. Findings suggest that CRHR1 variation may moderate the downstream effects of child maltreatment on HPA axis function, and implications for understanding mechanisms of risk associated with early adversity are discussed.
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影响因子：
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作者：
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