A unifying model of the role of the infralimbic cortex in extinction and habits.

A unifying model of the role of the infralimbic cortex in extinction and habits.
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DOI:
10.1101/lm.035501.114
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发表时间:
2014-09
期刊:
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子:
--
通讯作者:
Chandler LJ
Chandler LJ
中科院分区:
其他
文献类型:
--
作者:
Barker JM;Taylor JR;Chandler LJ

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边缘下前额叶皮层(infraalimbic prefrontal cortex,IL)对灵活行为的调节至关重要,但其确切功能尚不清楚。这一区域已被证明是至关重要的收购,巩固和灭绝学习的表达,导致许多人假设,IL抑制行为的一部分,“停止”网络。然而,这一框架与IL在习惯行为中的功能不一致,其中IL已被证明是表达和获得持续习惯行为所必需的。在这里,我们将审查目前的状态的知识IL的解剖和功能的行为灵活性,并提供一个可测试的框架,一个单一的IL机制,其功能在灭绝和习惯学习。
The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a “stop” network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning.
人类对食物图片的目标导向和习惯行为对腹内侧前额叶皮层的差异性参与。
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