A unifying model of the role of the infralimbic cortex in extinction and habits.
A unifying model of the role of the infralimbic cortex in extinction and habits.
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DOI:
10.1101/lm.035501.114
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发表时间:
2014-09
期刊:
影响因子:
--
通讯作者:
Chandler LJ
中科院分区:
文献类型:
--
作者:
Barker JM;Taylor JR;Chandler LJ
The infralimbic prefrontal cortex (IL) has been shown to be critical for the regulation of flexible behavior, but its precise function remains unclear. This region has been shown to be critical for the acquisition, consolidation, and expression of extinction learning, leading many to hypothesize that IL suppresses behavior as part of a “stop” network. However, this framework is at odds with IL function in habitual behavior in which the IL has been shown to be required for the expression and acquisition of ongoing habitual behavior. Here, we will review the current state of knowledge of IL anatomy and function in behavioral flexibility and provide a testable framework for a single IL mechanism underlying its function in both extinction and habit learning.
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