A review on neuroimaging studies of genetic and environmental influences on early brain development.
A review on neuroimaging studies of genetic and environmental influences on early brain development.
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DOI：
10.1016/j.neuroimage.2018.04.032
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发表时间：
2019-01-15
期刊：
影响因子：
5.7
通讯作者：
Gilmore JH
中科院分区：
文献类型：
--
作者：
Gao W;Grewen K;Knickmeyer RC;Qiu A;Salzwedel A;Lin W;Gilmore JH
在过去的几十年里，人们对正常和异常早期大脑发育的神经成像研究兴趣激增。对正常早期脑发育的结构和功能的研究揭示了婴儿期大量结构的成熟以及功能网络的有序、协调和层次化的出现，为研究异常早期脑发育机制提供了很好的基础。事实上，与遗传或环境风险相关的大脑发育改变的研究应运而生并蓬勃发展。在这篇文章中，我们将回顾已被相对广泛调查的遗传和环境风险的精选研究--遗传学方面的家族风险、候选风险基因和全基因组关联研究；环境方面的母亲情绪障碍和产前药物暴露。关于环境-基因相互作用的新研究也将被回顾。我们的目标不是对该领域的所有研究进行详尽的审查，而是利用一些具有代表性的研究来总结现状，指出潜在的局限性，并引发对未来重要方向的讨论。
The past decades witnessed a surge of interest in neuroimaging study of normal and abnormal early brain development. Structural and functional studies of normal early brain development revealed massive structural maturation as well as sequential, coordinated, and hierarchical emergence of functional networks during the infancy period, providing a great foundation for the investigation of abnormal early brain development mechanisms. Indeed, studies of altered brain development associated with either genetic or environmental risks emerged and thrived. In this paper, we will review selected studies of genetic and environmental risks that have been relatively more extensively investigated-familial risks, candidate risk genes, and genome-wide association studies (GWAS) on the genetic side; maternal mood disorders and prenatal drug exposures on the environmental side. Emerging studies on environment-gene interactions will also be reviewed. Our goal was not to perform an exhaustive review of all studies in the field but to leverage some representative ones to summarize the current state, point out potential limitations, and elicit discussions on important future directions.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
3.3
作者：
Bick J;Naumova O;Hunter S;Barbot B;Lee M;Luthar SS;Raefski A;Grigorenko EL
通讯作者：
Grigorenko EL
早产儿大脑连接组学分析揭示功能网络分离的早期发展
影响因子：
3.7
作者：
Cao, Miao;He, Yong;Huang, Hao
通讯作者：
Huang, Hao
影响因子：
4.2
作者：
Caddy, Caroline;Giaroli, Giovanni;Tracy, Derek K.
通讯作者：
Tracy, Derek K.
DOI：
10.1093/cercor/bhv203
发表时间：
2016-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Allievi AG;Arichi T;Tusor N;Kimpton J;Arulkumaran S;Counsell SJ;Edwards AD;Burdet E
通讯作者：
Burdet E