Does KMnO4 preoxidation reduce the genotoxicity of disinfection by-products?
Does KMnO4 preoxidation reduce the genotoxicity of disinfection by-products?
复制标题
KMnO4 预氧化是否可以降低消毒副产物的遗传毒性？
DOI：
10.1016/j.chemosphere.2016.08.018
复制
发表时间：
2016-11
期刊：
影响因子：
8.8
通讯作者：
Qu Jiuhui
中科院分区：
文献类型：
--
作者：
Chang Yangyang;Bai Yaohui;Qu Jiuhui
高锰酸钾（KMnO 4）预氧化能够影响消毒副产物（DBPs）的形成。然而，作为评价替代处理工艺的重要指标，KMnO 4预氧化后消毒副产物的毒性研究较少。本文采用SOS/umu试验研究了高锰酸钾预氧化对酪氨酸（Tyr）和2-羟基-4-甲氧基二苯甲酮-5-磺酸（BP-4）及其混合物氯化副产物的影响。结果表明，KMnO 4虽然不能氧化BP-4，但氯化后KMnO 4能氧化BP-4的氯化副产物，从而降低BP-4的遗传毒性。对于Tyr，KMnO 4预氧化可提高或降低DBP的遗传毒性，且与KMnO 4的剂量有关。确定了KMnO 4与Tyr的最佳初始摩尔比为1：1。实验证明，KMnO 4和KMnO 4还原产物MnO 2对Tyr的氧化作用以及MnO 2对氯化副产物的氧化作用均能降低氯化Tyr的遗传毒性。值得注意的是，在氯化过程中，锰（II）氧化与有机氧化的竞争可能导致更少的氯与有机物反应，导致遗传毒性增加。这是高锰酸钾预氧化后氯化酪氨酸遗传毒性增加的主要原因。此外，随着KMnO 4投加量的增加，氯化混合物的遗传毒性从高于氯化前体单独遗传毒性之和变为低于其单独遗传毒性之和，这是由于两种化合物的预氧化-氯化产物之间的联合作用。
Potassium permanganate (KMnO4) preoxidation is capable of affecting the formation of disinfection by-products (DBPs). However, few studies have focused on the toxicity of DBPs after KMnO4preoxidation, which is an important index to evaluate alternative treatment processes. Herein genotoxicity (SOS/umu test) was used to clarify the impact of KMnO4preoxidation on the chlorination byproducts produced from two representative precursors, tyrosine (Tyr) and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (BP-4), and their mixture. Results revealed that although KMnO4could not oxidize BP-4, after chlorination KMnO4could oxidize the chlorination byproducts of BP-4 and thus decrease the genotoxicity production. For Tyr, KMnO4preoxidation could increase or decrease the genotoxicity of DBPs, depending on the KMnO4dose. The optimal initial molar ratio of KMnO4to Tyr was confirmed to be 1:1. It has been proved that both the oxidation of Tyr by KMnO4and manganese dioxide (MnO2, the reduction product of KMnO4) and the oxidation of chlorination byproducts by MnO2can decrease the genotoxicity production of chlorinated Tyr. Remarkably, during chlorination, the competition of manganese(II) oxidation with organic oxidation can result in less chlorine reacting with organics, to induce an increase in genotoxicity. This is the main cause for the increase in genotoxicity of chlorinated Tyr after KMnO4preoxidation. Additionally, the genotoxicity of the chlorinated mixture was shifted from being higher than the sum of individual genotoxicities of the chlorinated precursors to being lower than their sum with increasing KMnO4dosage, due to the combined effects between the preoxidation-chlorination products from the two compounds.
登录
查看更多内容
影响因子：
11.8
作者：
L. Szajdak;R. Österberg
通讯作者：
L. Szajdak;R. Österberg
影响因子：
8.9
作者：
Chu, Wenhai;Gao, Naiyun;Yin, Daqiang
通讯作者：
Yin, Daqiang
影响因子：
11.4
作者：
Yang, Mengting;Zhang, Xiangru
通讯作者：
Zhang, Xiangru
影响因子：
3.6
作者：
R. Roelandts;J. Vanhee;A. Bonamie;L. Kerkhofs;H. Degreef
通讯作者：
R. Roelandts;J. Vanhee;A. Bonamie;L. Kerkhofs;H. Degreef
影响因子：
11.4
作者：
TREHY, ML;YOST, RA;MILES, CJ
通讯作者：
MILES, CJ