Declining walking impairment questionnaire scores are associated with subsequent increased mortality in peripheral artery disease.
Declining walking impairment questionnaire scores are associated with subsequent increased mortality in peripheral artery disease.
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DOI：
10.1016/j.jacc.2013.01.060
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发表时间：
2013-04-30
影响因子：
24
通讯作者：
McDermott MM
中科院分区：
文献类型：
--
作者：
Jain A;Liu K;Ferrucci L;Criqui MH;Tian L;Guralnik JM;Tao H;McDermott MM
这项研究确定了行走障碍问卷(WIQ)中楼梯攀登、距离或速度得分在两年内下降较大是否与患有下肢外周动脉疾病(PAD)的男性和女性的全原因和心血管疾病(CVD)死亡率较高相关。PAD患者的智商下降与死亡率之间的关联尚不清楚。参与者是来自芝加哥地区医疗中心的442名患有PAD的男性和女性。WIQ在基线和2年随访时完成。COX比例风险模型被用来评估两年内WIQ爬楼梯、WIQ距离和WIQ速度评分的变化类别与随后全因和心血管疾病死亡率的关系，调整了年龄、性别、种族、踝臂指数、体重指数、吸烟、合并症和其他协变量。123名参与者(27.8%)在WIQ得分测量改变两年后的中位数4.7年随访期内死亡。45名参与者死于心血管疾病。调整协变量后，在每个相应的WIQ类别中，WIQ得分下降的参与者的全因死亡率(风险比[HR]：1.93，95%可信区间[CI]：1.01~3.68；HR：2.34，95%CI：1.15~4.75；HR：3.55，95%CI：1.57~8.04)均高于≥评分提高20.0分的参与者。与≥评分提高20.0分的患者相比，≥评分下降20.0分的患者心血管病死率更高(HR：4.56，95%CI：1.3~16.01)。在WIQ爬楼梯、距离和速度评分中经历≥下降20.0分的PAD患者的全因死亡率高于在每个WIQ评分中下降较少的患者。(J Am Coll心脏ol 2013；61：1820-9)？2013由美国心脏病学会基金会主办
This study determined whether greater 2-year declines in Walking Impairment Questionnaire (WIQ) stair climbing, distance, or speed scores were associated with higher all-cause and cardiovascular disease (CVD) mortality among men and women with lower extremity peripheral artery disease (PAD). Associations of decline in the WIQ with mortality among people with PAD are unknown. Participants were 442 men and women with PAD identified from Chicago area medical centers. The WIQ was completed at baseline and at 2-year follow-up. Cox proportional hazard models were used to assess associations across categories of 2-year changes in WIQ stair climbing, WIQ distance, and WIQ speed scores with subsequent all-cause and CVD mortality, adjusting for age, sex, race, ankle-brachial index, body mass index, smoking, comorbidities, and other covariates. One hundred twenty-three participants (27.8%) died during a median follow-up of 4.7 years after the 2-year change in WIQ score measurements. Forty-five participants died from CVD. Adjusting for covariates, participants with WIQ score declines ≥20.0 points had higher all-cause mortality (hazard ratio [HR]: 1.93, 95% confidence interval [CI]: 1.01 to 3.68 for WIQ stair climbing; HR: 2.34, 95% CI: 1.15 to 4.75 for WIQ distance; and HR: 3.55, 95% CI: 1.57 to 8.04 for WIQ speed, respectively) compared with participants with ≥20.0 point improvement in each of the corresponding WIQ categories. Participants with ≥20.0 point declines in the WIQ distance score had higher CVD mortality (HR: 4.56, 95% CI: 1.30 to 16.01) compared with those with ≥20.0 point improvement in the WIQ distance score. Patients with PAD who experienced ≥20.0 point declines in the WIQ stair climbing, distance, and speed scores had a higher rate of all-cause mortality compared with those with less declines in each WIQ score. (J Am Coll Cardiol 2013;61:1820–9) © 2013 by the American College of Cardiology Foundation
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影响因子：
24
作者：
McDermott, Mary M.;Liu, Kiang;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
影响因子：
4.3
作者：
Jain, Atul;Liu, Kiang;McDermott, Mary M.
通讯作者：
McDermott, Mary M.
影响因子：
39.2
作者：
McDermott, MM;Greenland, P;Clark, E
通讯作者：
Clark, E
影响因子：
37.8
作者：
Garg, Parveen K.;Liu, Kiang;McDermott, Mary M.
通讯作者：
McDermott, Mary M.
影响因子：
3.5
作者：
Otero-Rodriguez, Andrea;Maria Leon-Munoz, Luz;Guallar-Castillon, Pilar
通讯作者：
Guallar-Castillon, Pilar