Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity
Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity
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区域同质性揭示阿尔茨海默病和轻度认知障碍的自发活动改变
DOI：
10.1016/j.neuroimage.2011.08.049
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发表时间：
2012-01
期刊：
影响因子：
5.7
通讯作者：
Wang, Luning
中科院分区：
文献类型：
--
作者：
Zhang, Zengqiang;Zhang, Xi;Liu, Yong;Jiang, Tianzi;Zhou, Bo;An, Ningyu;Dai, Haitao;Wang, Pan;Niu, Yixuan;Wang, Luning
阿尔茨海默病（Alzheimer's disease，AD）是老年人痴呆的最常见原因，其特征在于进行性认知和智力缺陷。大多数轻度认知障碍（MCI）患者被认为处于AD的非常早期阶段。静息态功能磁共振成像反映了自发性脑活动和/或人脑的内源性/背景神经生理过程。区域同质性（ReHo）可以提供一种快速的方法来映射整个大脑的区域活动。尽管之前的许多fMRI研究表明MCI/AD的活动模式发生了改变，但之前关于MCI和AD之间自发活动在哪里或如何不同的报道很少。在本研究中，我们首先使用ReHo方法探索正常对照组（NC）和MCI和AD患者全脑区域自发活动的差异。进行单因素方差分析以确定三组之间ReHo不同的区域，然后进行事后分析以评价三组之间模式的差异。最后对这些区域的ReHo指数与临床变量进行相关性分析，以评估AD和MCI组中ReHo与认知测量之间的关系。探索性分类分析还表明，ReHo测量能够在71.4%的病例中正确分离受试者。MCI和AD患者的内侧前额叶皮层、双侧扣带回/楔前叶后部和左侧顶下小叶（IPL）的自发活动均发生改变。MCI时，左侧IPL的ReHo指数高于NC，提示MCI时存在代偿机制。相关分析显示，MCI和AD患者的记忆及其他认知能力越低，ReHo越低。结合我们的研究结果与早期的研究结果，我们建议在静息状态下的自发活动模式可能被用作MCI/AD的临床标志物。
Alzheimer's disease (AD), the most prevalent cause of dementia in the elderly, is characterized by progressive cognitive and intellectual deficits. Most patients with mild cognitive impairment (MCI) are thought to be in a very early stage of AD. Resting-state functional magnetic resonance imaging reflects spontaneous brain activities and/or the endogenous/background neurophysiological process of the human brain. Regional Homogeneity (ReHo) can provide a fast method for mapping regional activity across the whole brain. Little has been previously published about where or how spontaneous activity differs between MCI and AD, although many previous fMRI studies have shown that the activity pattern is altered in MCI/AD. In the present study, we first used the ReHo method to explore differences in regional spontaneous activities throughout the whole brain between normal controls (NC) and people with MCI and with AD. A one-way ANOVA was performed to determine the regions in which the ReHo differs between the three groups, and then a post hoc analysis was performed to evaluate differences in the pattern among the three groups. Finally a correlation analysis was done between the ReHo index of these regions and clinical variables in order to evaluate the relationship between ReHo and cognitive measures in the AD and MCI groups. An exploratory classification analysis also demonstrated that ReHo measures were able to correctly separate subjects in 71.4% of the cases. Altered brain spontaneous activations were found in the medial prefrontal cortex, the bilateral posterior cingulate gyrus/precuneus and the left inferior parietal lobule (IPL) in both MCI and AD. In MCI, the ReHo index in the left IPL was higher than that of the NC, which could indicate the presence of a compensatory mechanism in MCI. More obviously, the correlation analysis indicated that the lower the memory and other cognitive abilities, the lower the ReHo in patients with MCI and AD. Combining our findings with the results in earlier studies, we propose that the spontaneous activity pattern in the resting state could potentially be used as a clinical marker for MCI/AD.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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