Small extracellular vesicles in cancer.
Small extracellular vesicles in cancer.
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DOI：
10.1016/j.bioactmat.2021.03.015
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发表时间：
2021-11
影响因子：
18.9
通讯作者：
Wan Y
中科院分区：
文献类型：
--
作者：
Abhange K;Makler A;Wen Y;Ramnauth N;Mao W;Asghar W;Wan Y
细胞外囊泡（extracellular vesicles，EV）是由细胞释放的亚微米大小的脂质双层囊泡。包括蛋白质、DNA片段、RNA、脂质和代谢物在内的多种分子可以选择性地封装到EV中并递送到附近和远处的受体细胞。在肿瘤中，通过这种细胞间通讯，EV可以调节肿瘤的发生、生长、转移和侵袭。最近的研究发现，EV表现出模仿亲本细胞的特异性表达模式，为早期癌症诊断和预后以及监测治疗反应提供了指纹。因此，为了研究和诊断目的，已经开发了各种EV分离和检测技术。此外，天然和工程EV也已被用作药物递送纳米载体、癌症疫苗、细胞表面调节剂、治疗剂和治疗靶标。总的来说，EV正在进行深入的研究，因为它们有望用于病理生理学和转化发现。这篇全面的综述研究了过去五年来EV的最新研究趋势，包括它们在癌症病理生理学、诊断学和治疗学中的作用。这篇综述的目的是检查肿瘤EV研究的全方位，并提供一个全面的基础，以提高该领域。本综述中讨论和审查的主题包括分离技术以及如何克服这些问题，以用于基于EV的诊断，EV及其在癌症生物学中的作用，用于诊断和监测的生物标志物，EV作为疫苗，治疗靶点以及EV作为药物递送系统。我们还将研究EV研究所面临的挑战，并促进促进以肿瘤EV为重点的研究的科学发现和创新的框架。介绍了基于细胞外小泡（sEV）的肿瘤基础和临床研究的全谱。这是为数不多的系统介绍/总结sEV在癌症研究中的综合性综述之一。审查的主题将推进科学的前沿，突出挑战，并支持高等教育。
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids, and metabolites can be selectively encapsulated into EVs and delivered to nearby and distant recipient cells. In tumors, through such intercellular communication, EVs can regulate initiation, growth, metastasis and invasion of tumors. Recent studies have found that EVs exhibit specific expression patterns which mimic the parental cell, providing a fingerprint for early cancer diagnosis and prognosis as well as monitoring responses to treatment. Accordingly, various EV isolation and detection technologies have been developed for research and diagnostic purposes. Moreover, natural and engineered EVs have also been used as drug delivery nanocarriers, cancer vaccines, cell surface modulators, therapeutic agents and therapeutic targets. Overall, EVs are under intense investigation as they hold promise for pathophysiological and translational discoveries. This comprehensive review examines the latest EV research trends over the last five years, encompassing their roles in cancer pathophysiology, diagnostics and therapeutics. This review aims to examine the full spectrum of tumor-EV studies and provide a comprehensive foundation to enhance the field. The topics which are discussed and scrutinized in this review encompass isolation techniques and how these issues need to be overcome for EV-based diagnostics, EVs and their roles in cancer biology, biomarkers for diagnosis and monitoring, EVs as vaccines, therapeutic targets, and EVs as drug delivery systems. We will also examine the challenges involved in EV research and promote a framework for catalyzing scientific discovery and innovation for tumor-EV-focused research. The full spectrum of small extracellular vesicles (sEV) based cancer fundamental and clinical studies is introduced. It is one of very few comprehensive reviews that systematically introduce/summarize sEV in cancer research. The reviewed topics will advance the frontiers of science, highlight challenges, and support higher education.
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DOI：
10.1111/j.1538-7836.2008.03087.x
发表时间：
2008-09
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Aghajanian A;Wittchen ES;Allingham MJ;Garrett TA;Burridge K
通讯作者：
Burridge K
影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
DOI：
10.3390/s17030449
发表时间：
2017-02-24
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Abd Rahman N;Ibrahim F;Yafouz B
通讯作者：
Yafouz B
影响因子：
8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Antimisiaris SG;Mourtas S;Marazioti A
通讯作者：
Marazioti A