β-Endorphin Induction by Psychological Stress Promotes Leydig Cell Apoptosis through p38 MAPK Pathway in Male Rats
β-Endorphin Induction by Psychological Stress Promotes Leydig Cell Apoptosis through p38 MAPK Pathway in Male Rats
复制标题
心理应激诱导β-内啡肽通过 p38 MAPK 通路促进雄性大鼠间质细胞凋亡
作者：
Xiong Xiaofan;Zhang Lingyu;Fan Meiyang;Han Lin;Wu Qiuhua;Liu Siyuan;Miao Jiyu;Liu Liying;Wang Xiaofei;Guo Bo;Tong Dongdong;Ni Lei;Yang Juan;Huang Chen
心理应激（psychological stress，PS）干扰生殖内分泌系统，促进男性不育，但其致病机制尚未得到广泛研究。本研究的目的是揭示PS诱导雄性生殖相关异常的机制。PS组雄性大鼠生长缓慢，精子质量下降，生殖内分泌激素水平异常，生殖相关蛋白雄激素结合蛋白（ABP）和含溴结构域蛋白（BRDT）表达降低，睾丸细胞凋亡增加，并伴有β-内啡肽（β-EP）水平升高。这些作用被纳洛酮逆转。此外，PS诱导的β-EP可促进μ阿片受体（莫尔）的激活，使细胞内p38 MAPK磷酸化，进而导致Leydig细胞（LC）凋亡。本研究结果提示β-EP是PS致雄性不育的一个关键因素。
Psychological stress (PS) disturbs the reproductive endocrine system and promotes male infertility, but the underlying pathogenic mechanisms have not been extensively studied. This study aimed to uncover the mechanisms of PS-induced male reproductive related abnormalities subjected to a ‘terrified sound’ exposure. Male rats subjected to PS displayed slow growth, decreased sperm quality, abnormal levels of the reproductive endocrine hormones, decreased expression of the reproductive-related proteins androgen-binding protein (ABP) and bromodomain-containing protein (BRDT), increased apoptosis in the testis, and accompanied by elevated levels of β-endorphin (β-EP). These effects were reversed by naloxone. Furthermore, PS-induced β-EP could promote mu opioid receptor (MOR) activation and ensure intracellular p38 MAPK phosphorylation and then lead to Leydig cells (LCs) apoptosis. The current result showed that β-EP was a key factor to PS-induced male infertility.
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影响因子：
64.8
作者：
SHENKER, A;LAUE, L;CUTLER, GB
通讯作者：
CUTLER, GB
DOI：
10.1016/j.kjms.2015.10.009
发表时间：
2015-12
期刊：
The Kaohsiung Journal of Medical Sciences
影响因子：
--
作者：
Shuo Yan;Zili You;Qiuying Zhao;Cheng Peng;Gang He;X. Gou;Bin Lin
通讯作者：
Shuo Yan;Zili You;Qiuying Zhao;Cheng Peng;Gang He;X. Gou;Bin Lin
影响因子：
64.5
作者：
Matzuk MM;McKeown MR;Filippakopoulos P;Li Q;Ma L;Agno JE;Lemieux ME;Picaud S;Yu RN;Qi J;Knapp S;Bradner JE
通讯作者：
Bradner JE
影响因子：
2.9
作者：
S. El-Haggar;S. El-Ashmawy;A. Attia;T. Mostafa;M. Roaiah;A. Fayez;S. Ghazi;W. Zohdy;N. Roshdy
通讯作者：
S. El-Haggar;S. El-Ashmawy;A. Attia;T. Mostafa;M. Roaiah;A. Fayez;S. Ghazi;W. Zohdy;N. Roshdy
影响因子：
13.6
作者：
Li MW;Mruk DD;Cheng CY
通讯作者：
Cheng CY