Measuring the thickness of vertebral endplate and shell using digital tomosynthesis.
Measuring the thickness of vertebral endplate and shell using digital tomosynthesis.
复制标题
DOI：
10.1016/j.bone.2022.116341
复制
发表时间：
2022-04
期刊：
影响因子：
4.1
通讯作者：
Flynn MJ
中科院分区：
文献类型：
--
作者：
Yeni YN;Dix MR;Xiao A;Oravec DJ;Flynn MJ
椎体终板和皮质壳起着重要的结构作用，有助于椎体的整体力量，是初始失败的最高风险，并参与脊柱退行性疾病。因此，准确测量这些结构的厚度的能力是重要的，即使由于相对较低的分辨率临床成像很困难。我们认为，数字断层合成(DTS)可能是一种适合于测量终板和皮质外壳厚度的成像方式，因为它能够在低辐射剂量下重建具有良好空间分辨率的多平面图像。在这项研究中，对25个身体L1椎体的终板和皮质壳厚度的平均偏差和标准差进行了测量，使用的图像来自DTS和显微计算机断层扫描(μCT)。对于终板厚度的测量，当比较在整个终板体积中测量的厚度(R2=0.25-0.54)和当测量限于冠状或矢状面切片的中心范围(R2=0.24-0.62)时，所有变量的DTS和μCT之间都发现了显著的相关性。当与整个壳体体积的参考值相比时，DTS厚度测量通常是不重要的。然而，当测量皮质壳层厚度限于一定范围的中央薄片时，DTS结果与矢状面和冠状面中央区域的参考值显著相关(R2=0.21-0.49)。因此，DTS可以提供一种测量终板厚度的方法，并且在有限的矢状面或冠状面测量体积内，可以测量皮质壳层厚度。
The vertebral endplate and cortical shell play an important structural role and contribute to the overall strength of the vertebral body, are at highest risk of initial failure, and are involved in degenerative disease of the spine. The ability to accurately measure the thickness of these structures is therefore important, even if difficult due to relatively low resolution clinical imaging. We posit that digital tomosynthesis (DTS) may be a suitable imaging modality for measurement of endplate and cortical shell thickness owing to the ability to reconstruct multiplanar images with good spatial resolution at low radiation dose. In this study, for 25 cadaveric L1 vertebrae, average and standard deviation of endplate and cortical shell thickness were measured using images from DTS and microcomputed tomography (μCT). For endplate thickness measurements, significant correlations between DTS and μCT were found for all variables when comparing thicknesses measured in both the overall endplate volume (R2=0.25–0.54) and when measurements were limited to a central range of coronal or sagittal slices (R2=0.24–0.62). When compared to reference values from the overall shell volume, DTS thickness measurements were generally nonsignificant. However, when measurement of cortical shell thickness was limited to a range of central slices, DTS outcomes were significantly correlated with reference values for both sagittal and coronal central regions (R2=0.21–0.49). DTS may therefore offer a means for measurement of endplate thickness and, within a limited sagittal or coronal measurement volume, for measurement of cortical shell thickness.
登录
查看更多内容
影响因子：
3
作者：
Cao, K D;Grimm, M J;Yang, K H
通讯作者：
Yang, K H
影响因子：
3
作者：
Homminga, J;Weinans, H;Huiskes, R
通讯作者：
Huiskes, R
影响因子：
2.8
作者：
Jackman, Timothy M.;Hussein, Amira I.;Morgan, Elise F.
通讯作者：
Morgan, Elise F.
影响因子：
3
作者：
BRINCKMANN, P;FROBIN, W;HORST, M
通讯作者：
HORST, M
查看双重：比较双层和单层椎骨终结之间的微观结构，生物力学功能和相邻的椎间盘健康。
影响因子：
3
作者：
Fields AJ;Sahli F;Rodriguez AG;Lotz JC
通讯作者：
Lotz JC