Neurotrophic effects of neudesin in the central nervous system.
Neurotrophic effects of neudesin in the central nervous system.
复制标题
DOI：
10.3389/fnins.2013.00111
复制
发表时间：
2013
影响因子：
4.3
通讯作者：
Itoh N
中科院分区：
文献类型：
--
作者：
Kimura I;Nakayama Y;Zhao Y;Konishi M;Itoh N
神经营养因子(Neudesin，Neudesin)是一种神经营养因子，参与神经元的分化和存活。它在中枢神经系统中大量表达，其神经营养活性通过丝裂原活化蛋白激酶(MAPK)和磷脂酰肌醇3-激酶(PI3K)途径发挥作用。Neudesin也是一种厌食因子，可以抑制下丘脑的食物摄取。它是膜相关孕激素受体(MAPR)家族的成员，与细胞色素b5样血红素/类固醇结合结构域具有共同的关键结构基序。孕酮受体膜组分1(PGRMC1)是在MAPR家族中首次发现的，它与孕酮结合，在与核孕激素受体(PR)无关的生物反应中诱导“快速的非基因组效应”。因此，neudesin也可能参与黄体酮的快速非基因组作用。在这篇综述中，我们综述了neudesin在中枢神经系统中的鉴定、结构和活性，并对目前对其生理作用的了解以及阐明其非基因组孕酮作用的前景进行了必要的概述。
Neudesin (neuron-derived neurotrophic factor; NENF) was identified as a neurotrophic factor that is involved in neuronal differentiation and survival. It is abundantly expressed in the central nervous system, and its neurotrophic activity is exerted via the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. Neudesin is also an anorexigenic factor that suppresses food intake in the hypothalamus. It is a member of the membrane-associated progesterone receptor (MAPR) family and shares key structural motifs with the cytochrome b5-like heme/steroid-binding domain. Progesterone receptor membrane component 1 (PGRMC1), the first to be discovered among the MAPR family, binds progesterone to induce “rapid non-genomic effects” in biological responses that are unrelated to the nuclear progesterone receptors (PRs). Hence, neudesin may also be involved in the rapid non-genomic actions of progesterone. In this review, we summarize the identification, structure, and activity of neudesin in the central nervous system, and present an essential overview of the current understanding of its physiological roles and the prospect of elucidating its non-genomic progesterone effects.
登录
查看更多内容
G蛋白偶联的雌激素受体GPER在健康和疾病中。
DOI：
10.1038/nrendo.2011.122
发表时间：
2011-08-16
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.7
作者：
Peluso, John J.
通讯作者：
Peluso, John J.
DOI：
10.1016/j.bbrc.2009.02.011
发表时间：
2009-03-27
影响因子：
3.1
作者：
Kimura, Ikuo;Konishi, Morichika;Fujimoto, Masafumi
通讯作者：
Fujimoto, Masafumi
影响因子：
2.9
作者：
Neubauer, Hans;Clare, Susan E.;Cahill, Michael A.
通讯作者：
Cahill, Michael A.
DOI：
10.1046/j.1365-2362.2000.0300s3051.x
发表时间：
2000-12-01
影响因子：
5.5
作者：
Falkenstein, E;Wehling, M
通讯作者：
Wehling, M