Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex.
Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex.
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DOI：
10.1016/j.isci.2023.105947
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发表时间：
2023-02-17
期刊：
影响因子：
5.8
通讯作者：
Thiele, Alexander
中科院分区：
文献类型：
--
作者：
Smart, Caitlin;Mitchell, Anna;McCutcheon, Fiona;Medcalf, Robert L.;Thiele, Alexander
组织型纤溶酶原激活剂 (tPA) 是一种丝氨酸蛋白酶，在大脑的各个区室中表达。它与神经元可塑性、学习和记忆以及成瘾有关。我们评估了外源性应用的 tPA 是否会影响小鼠听觉皮层内的神经可塑性。我们使用频率配对范例来确定神经元最佳频率是否按照配对协议发生变化。 tPA 给药显着影响配对后的最佳频率，这取决于相对于最佳频率的配对频率。当配对频率高于最佳频率时，tPA 会导致最佳频率偏离调节频率。 tPA 显着拓宽了听觉调谐曲线。我们的数据表明，听觉皮层内蛋白水解活性的区域变化调节听觉神经元的微调，支持 tPA 作为神经元可塑性调节剂的功能。组织型纤溶酶原激活剂导致听觉皮层可塑性神经元最佳频率偏离调节音频率听觉频谱调谐曲线在调节音频率后变宽细胞生物学；感觉神经科学
Tissue-type plasminogen activator (tPA) is a serine protease that is expressed in various compartments in the brain. It is involved in neuronal plasticity, learning and memory, and addiction. We evaluated whether tPA, exogenously applied, could influence neuroplasticity within the mouse auditory cortex. We used a frequency-pairing paradigm to determine whether neuronal best frequencies shift following the pairing protocol. tPA administration significantly affected the best frequency after pairing, whereby this depended on the pairing frequency relative to the best frequency. When the pairing frequency was above the best frequency, tPA caused a best frequency shift away from the conditioned frequency. tPA significantly widened auditory tuning curves. Our data indicate that regional changes in proteolytic activity within the auditory cortex modulate the fine-tuning of auditory neurons, supporting the function of tPA as a modulator of neuronal plasticity. Tissue-type plasminogen activator causes auditory cortical plasticity Neuronal best frequencies shift away from conditioning tone frequencies Auditory spectral tuning curves widen following conditioning tone frequencies Cell biology; Sensory neuroscience
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影响因子：
5.6
作者：
Hedou E;Douceau S;Chevilley A;Varangot A;Thiebaut AM;Triniac H;Bardou I;Ali C;Maillasson M;Crepaldi T;Comoglio P;Lemarchand E;Agin V;Roussel BD;Vivien D
通讯作者：
Vivien D
影响因子：
2.5
作者：
Ego-Stengel, V;Shulz, DE;Ahissar, E
通讯作者：
Ahissar, E
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1038/npp.2010.104
发表时间：
2011-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.4
作者：
Henny, Pablo;Jones, Barbara E.
通讯作者：
Jones, Barbara E.