Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
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DOI：
10.1016/j.schres.2010.01.019
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发表时间：
2010-05
影响因子：
4.5
通讯作者：
Keshavan, Matcheri S.
中科院分区：
文献类型：
--
作者：
Bhojraj, Tejas S.;Prasad, Konasale M.;Eack, Shaun M.;Francis, Alan N.;Montrose, Debra M.;Keshavan, Matcheri S.
关键词：
精神分裂症患者及其亲属在默认网络区域（DR）（如内侧前额叶、外侧颞叶、扣带回和下顶叶皮质）和执行区域（如背外侧前额叶皮质（DLPFC））中显示出异常的功能连接。灰质体积的改变可能与这些功能连接缺陷。此外，灰质体积区域间的相关性可能反映了改变区域间的功能连接。研究我们对精神分裂症患者（OS）后代DR和DLPFC的灰质体积改变和区域间体积相关性的预测。我们使用T1-MRI评估了64名青少年和年轻成人OS和80名健康对照（HC）。比较各组间DR之间以及DLPFC和每侧DR之间的区域灰质体积和区域间体积相关性。与HC相比，在控制年龄、性别和颅内体积并校正多重比较后，OS在几个DR和DLPFC中降低。OS在DR之间以及DR与DLPFC之间具有更强（更正）的灰质体积相关性。默认网络和DLPFC中的体积缺陷可能与精神分裂症的家族素质和家族风险中的功能连接异常有关。DR之间以及DR和DLPFC灰质体积之间的相互关联增加可以作为异常功能连接的替代指标。
Schizophrenia patients and their relatives show aberrant functional connectivity in default network regions (DRs) such as the medial prefrontal, lateral temporal, cingulate and inferior parietal cortices and executive regions such as the dorsolateral prefrontal cortex (DLPFC). Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity. To examine our prediction of alterations of gray-matter volumes and inter-regional volume correlations for DRs and the DLPFC in offspring of schizophrenia patients (OS). We assessed 64 adolescent and young adult OS and 80 healthy controls (HC) using T1-MRI. Regional gray-matter volumes and inter-regional volume correlations between the DRs and between the DLPFC and DRs on each side were compared across groups. Compared to HC, OS had reductions in several DRs and the DLPFC after controlling age, gender, and intra-cranial volume, and correcting for multiple comparisons. OS had stronger (more positive) gray-matter volume inter-correlations between DRs and between DRs and the DLPFC. Volumetric deficits in the default network and in the DLPFC may be related to familial diathesis to schizophrenia and to functional connectivity abnormalities in those at familial risk. Increased inter-correlations between DRs and between DR and DLPFC gray-matter volumes may serve as surrogate indices of abnormal functional connectivity.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume
影响因子：
5.7
作者：
Jafri, Madiha J.;Pearlson, Godfrey D.;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
影响因子：
17.7
作者：
Gilbert, AR;Rosenberg, DR;Keshavan, MS
通讯作者：
Keshavan, MS
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.