Incubation of ethanol reinstatement depends on test conditions and how ethanol consumption is reduced.
Incubation of ethanol reinstatement depends on test conditions and how ethanol consumption is reduced.
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DOI：
10.1016/j.beproc.2015.01.002
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发表时间：
2015-04
影响因子：
1.3
通讯作者：
Lamb, R. J.
中科院分区：
文献类型：
--
作者：
Ginsburg, Brett C.;Lamb, R. J.
在复吸研究（研究复发的常见临床前程序）中，会发生潜伏期（更长的禁欲期导致更多的反应）。这一发现与临床文献不一致。确定潜伏期的决定因素有助于解释复吸和确定复吸所涉及的过程。在接受训练的大鼠中检查恢复的反应，以在多个并行时间表下对乙醇和食物作出反应（组分1：乙醇FR 5，食物FR 150;组分2：乙醇FR 5，食物FR 5-在30分钟的时间段内交替）。然后通过暂停训练（大鼠留在饲养笼中）或通过提供替代强化（整个训练期仅提供组分2刺激和意外事件）减少乙醇消耗1或16个训练期。在下一个会话中，呈现与组件1相关的刺激并记录响应，但从未提供乙醇和食物。两个测试条件进行了研究：固定比例完成产生乙醇或食物相关的刺激（信号）或没有编程的后果（无信号）。只有在发出信号的测试期间暂停训练后才观察到乙醇反应的潜伏。暂停训练后，还观察到食物反应的孵化。这些结果是最一致的孵化导致的反馈功能的退化限制灭绝反应，而不是增加的动机。
In reinstatement studies (a common preclinical procedure for studying relapse), incubation occurs (longer abstinence periods result in more responding). This finding is discordant with the clinical literature. Identifying determinants of incubation could aid in interpreting reinstatement and identifying processes involved in relapse. Reinstated responding was examined in rats trained to respond for ethanol and food under a multiple concurrent schedule (Component 1: ethanol FR5, food FR150; Component 2: ethanol FR5, food FR5–alternating across the 30-min session). Ethanol consumption was then reduced for 1 or 16 sessions either by suspending training (rats remained in home cage) or by providing alternative reinforcement (only Component 2 stimuli and contingencies were presented throughout the session). In the next session, stimuli associated with Component 1 were presented and responses recorded but ethanol and food were never delivered. Two test conditions were studied: fixed-ratio completion either produced ethanol- or food-associated stimuli (signaled) or had no programmed consequence (unsignaled). Incubation of ethanol responding was observed only after suspended training during signaled test sessions. Incubation of food responding was also observed after suspended training. These results are most consistent with incubation resulting from a degradation of feedback functions limiting extinction responding, rather than an increased motivation.
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影响因子：
5.6
作者：
Bienkowski, P;Rogowski, A;Kostowski, W
通讯作者：
Kostowski, W
影响因子：
2.7
作者：
Dinsmoor, JA
通讯作者：
Dinsmoor, JA
DOI：
10.1901/jeab.1962.5-s543
发表时间：
1962-01-01
期刊：
JOUR EXPTL ANALYSIS BEHAVIOR
影响因子：
--
作者：
KELLEHER, ROGER T.;GOLLUB, LEWIS R.
通讯作者：
GOLLUB, LEWIS R.
影响因子：
2.7
作者：
Li, Chen;Frantz, Kyle J.
通讯作者：
Frantz, Kyle J.
影响因子：
3.1
作者：
GOSSOP, M;GREEN, L;BRADLEY, B
通讯作者：
BRADLEY, B