Roles of galectins in infection.

Roles of galectins in infection.
复制标题

甲状腺素在感染中的作用。

DOI:
10.1038/nrmicro2146
复制
发表时间:
2009-06
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
--
中科院分区:
其他
文献类型:
--
作者:

文献摘要

参考文献

被引文献

相似文献

半乳糖凝集素首次在 20 世纪 70 年代中期被表征,被认为在胚胎发生、发育和免疫调节中识别内源性(“自身”)碳水化合物配体中发挥作用。然而,最近,半乳糖凝集素已被证明可以结合潜在病原微生物表面上的聚糖,并在先天免疫中充当识别和效应因子。一些寄生虫破坏载体或宿主半乳糖凝集素的识别作用,以确保成功附着或入侵。本综述讨论了半乳糖凝集素在微生物感染中的作用,特别强调病原体对宿主半乳糖凝集素介导的免疫反应的逃避或破坏的适应。
Galectins, which were first characterized in the mid-1970s, were assigned a role in the recognition of endogenous (‘self) carbohydrate ligands in embryogenesis, development and immune regulation. Recently, however, galectins have been shown to bind glycans on the surface of potentially pathogenic microorganisms, and function as recognition and effector factors in innate immunity. Some parasites subvert the recognition roles of the vector or host galectins to ensure successful attachment or invasion. This Review discusses the role of galectins in microbial infection, with particular emphasis on adaptations of pathogens to evasion or subversion of host galectin-mediated immune responses.
酿酒酵母中蛋白质出口的新途径。
DOI: 10.1083/jcb.133.5.1017
发表时间: 1996-06
影响因子: 7.8
作者:
Cleves, AE;Cooper, DNW;Barondes, SH;Kelly, RB
通讯作者: Kelly, RB
DOI: 10.2353/ajpath.2006.050636
发表时间: 2006-06-01
影响因子: 6
作者:
Bernardes, Emerson Soares;Silva, Neide M.;Roque-Barreira, Maria Cristina
通讯作者: Roque-Barreira, Maria Cristina
DOI: 10.1017/s0031182005009510
发表时间: 2006-04-01
期刊: PARASITOLOGY
影响因子: 2.4
作者:
Craig, H;Wastling, JM;Knox, DP
通讯作者: Knox, DP
DOI: 10.1038/nsb817
发表时间: 2002-08-01
期刊: NATURE STRUCTURAL BIOLOGY
影响因子: --
作者:
Bianchet, MA;Odom, EW;Amzel, LM
通讯作者: Amzel, LM
DOI: 10.1016/s0014-4894(02)00026-7
发表时间: 2002-04-01
影响因子: 2.1
作者:
Basseri, HR;Tew, IF;Ratcliffe, NA
通讯作者: Ratcliffe, NA