Control of ESX-1 virulence secretion by the espA-espC-espD operon in Mycobacterium tuberculosis: molecular characterization and potential for anti-virulence drug development.

结核分枝杆菌中 espA-espC-espD 操纵子对 ESX-1 毒力分泌的控制：分子特征和抗毒力药物开发的潜力。

• 批准号: 203274
• 负责人: Chen Jeffrey M
• 金额: $ 7.29万
• 依托单位: Swiss Federal Institute of Technology in Lausanne
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-02-01 至 2012-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=203274&lang=en
• 关键词: Cellular Microbiology; Chemical Biology; Chemical Genetics; Functional Genomics; Molecular Mycobacteriology; Mycobacterial Genetics; Mycobacterial Pathogenesis; Protein Biochemistry; Proteomics; Structural Biology

Mycobacterium tuberculosis (M. tb) inflicts enormous human suffering. Every year, two million individuals die and eight million more are infected by this deadly air-borne pathogen. Exacerbating this grim statistic is the proliferation of multi- and extens

结核分枝杆菌（M. tb）给人类带来巨大痛苦。每年有200万人死于这种致命的空气传播病原体，另有800万人受到感染。使这一严峻的统计数据更加恶化的是多重和广泛的扩散