Novel Wnt paracrine signaling mediated by the intestinal extracellular calcium-sensing receptor (CaSR) inhibits defective Wnt signaling and stimulates differentiation.
Novel Wnt paracrine signaling mediated by the intestinal extracellular calcium-sensing receptor (CaSR) inhibits defective Wnt signaling and stimulates differentiation.
批准号:
178985
负责人:
Macleod R. John
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2008
资助国家:
加拿大
项目状态:
已结题
起止时间:
2008-09-01 至 2009-09-01
中文摘要
结直肠癌是一种Wnt信号缺陷的疾病,在加拿大是导致癌症死亡的第三大常见原因。肠道发炎会增加患结直肠癌的风险。饮食中钙的增加可减少结肠炎的发病
英文摘要
Colorectal cancer is a disease of defective Wnt signaling which is the third most common cause of cancer-deaths in Canada. Inflammation of the intestine increases the risk for colorectal cancer. Increases in dietary calcium reduce the onset of colonic p
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