Novel compounds to disrupt protein-protein interactions

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Many diseases involve aberrant interactions between proteins. Strategies to inhibit such interactions have potential as tool reagents for biological research but also as new therapies. Most drugs currently used in the clinic are small organic molecules, though these typically are not effective at disrupting protein complexes, hence alternatives are required. This proposal to examine foldamers as a novel strategy for inhibiting protein: protein interactions could lead to the development of new drugs for the treatment of diseases where the current traditional approaches have proven ineffective.