Structure and function of Bcl-2 family proteins

Bcl-2家族蛋白的结构和功能

• 批准号: nhmrc : 1116934
• 负责人: Prof Peter Colman
• 金额: $ 59.07万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-bcl-family-proteins/946114
• 关键词: Structure; function; Bcl; family; proteins

A common characteristic of cancer is the failure of cells to die when they normally would. One of the problems with many cancer therapies is that they rely on the integrity of signalling pathways to the normal ‘death machinery’ of the cell to do their job. By understanding how the molecular death machine operates we are fashioning new drugs that can target it directly, thus bypassing the very pathways that are so frequently disrupted in tumour cells.

癌症的一个共同特征是细胞在正常情况下不能死亡。许多癌症疗法的一个问题是，它们依赖于细胞正常“死亡机制”信号通路的完整性来完成它们的工作。通过了解分子死亡机器是如何运作的，我们正在研制可以直接针对它的新药，从而绕过肿瘤细胞中经常被破坏的途径。