Evaluating the role of organic anion-transporting polypeptide 2B1 in food-drug interactions

评估有机阴离子转运多肽 2B1 在食物-药物相互作用中的作用

• 批准号: 331306
• 负责人: Li Mandy M
• 金额: $ 1.27万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-12-01 至 2015-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331306&lang=en
• 关键词: Absorption; Bioavailability; Fexofenadine; Food-Drug Interaction; Grapefruit Juice; Heterologous Expression; Knockout Mouse; Oatp2b1; Pharmacokinetics; Transporter

When oral medications, such as fexofenadine, an antihistamine, are ingested together with grapefruit juice (GFJ), the amount of drug absorbed into the body is reduced. This may lead to decreased drug levels and therefore lower drug response. It has been s

当口服药物，如非索非那定（一种抗组胺药）与葡萄柚汁（GFJ）一起摄入时，被人体吸收的药物量就会减少。这可能导致药物水平降低，从而降低药物反应。已经5年了。