Studies on peripheral T cell memory

外周T细胞记忆研究

• 批准号: DP1094957
• 负责人: Prof Francis Carbone
• 金额: $ 89.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094957
• 关键词: Studies; peripheral; cell; memory

Success in vaccination depends on the ability of the immune system to remember prior encounter with an infectious agent. This immune memory appears to work well for certain infections but not others, essentially meaning that for these diseases, effective vaccines remain unavailable. This application describes experiments based on a new leukocyte or white blood cell population that has been overlooked in studies of immune memory. The work involves identifying how they are formed and how they behave within the body. This work will therefore contribute to the development and production of new-generation vaccines to these so far uncontrollable infectious diseases.

疫苗接种的成功取决于免疫系统记住先前与传染原接触的能力。 这种免疫记忆似乎对某些感染有效，但对其他感染无效，这基本上意味着对于这些疾病，有效的疫苗仍然不可用。 本申请描述了基于在免疫记忆研究中被忽视的新的白细胞或白色血细胞群体的实验。这项工作涉及确定它们是如何形成的，以及它们在体内的行为方式。 因此，这项工作将有助于开发和生产针对这些迄今无法控制的传染病的新一代疫苗。