Subset Determination of Tissue-Resident T cell Memory

组织驻留 T 细胞记忆的子集测定

• 批准号: nhmrc : 1146711
• 负责人: Prof Francis Carbone
• 金额: $ 31.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/subset-determination-tissue-cell-memory/1320721
• 关键词: Subset; Determination; Tissue; Resident; cell

Immunity relies on white blood cells called T cells that circulate around the body and which are also found permanently lodged at body surfaces. It is non-circulating T cells that are the most important in protecting against infection. In this application we propose to show that only a subset of T cells can form the resident population and to identify the molecules that determine T cell residency. This information can then be used for the efficient construction of disease preventing vaccines.

免疫力依赖于被称为T细胞的白色血细胞，T细胞在身体周围循环，也被发现永久地停留在身体表面。非循环T细胞在保护免受感染方面最重要。在本申请中，我们提出，只有一个子集的T细胞可以形成居民人口，并确定的分子，决定T细胞的居留权。这些信息可用于有效构建疾病预防疫苗。