Control of the antigen-specific cytotoxic T cell memory response

抗原特异性细胞毒性 T 细胞记忆反应的控制

• 批准号: nhmrc : 145754
• 负责人: Prof Francis Carbone
• 金额: $ 6.34万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-antigen-specific-memory-response/99453
• 关键词: Control; antigen; specific; cytotoxic; cell

Individuals who survive infections by a given pathogenic micro-organism are usually protected from subsequent infections by these same agents. This is the basis of adaptive immunity, which defines the body's ability to maintain a memory of prior infection or vaccination and in so doing, mount a far more effective response to subsequent infection by these agents. This proposal deals with the mechanisms by which this memory is maintained. It specifically focuses on cytotoxic T lymphocytes (CTL) which are leucocytes or white blood cells that kill virus infected cells. Using new technology which permits visualisation of CTL directed against specific viruses we are going to define what determines the survival and replacement of these memory cells over time. We will also identify the agents that alter the memory CTL's ability to deal with infections within localised sites in the body. In so doing, this work will provide valuable insight into approaches that can be used to better vaccinate individuals against infections by pathogenic viruses.

在感染特定病原微生物后幸存的个人通常会受到保护，免受这些病原体的后续感染。这是适应性免疫的基础，适应性免疫定义了身体保持先前感染或接种疫苗的记忆的能力，并且在这样做的过程中，对这些因子的后续感染产生更有效的反应。这一建议涉及的是维持这种记忆的机制。它特别关注细胞毒性T淋巴细胞（CTL），其是杀死病毒感染细胞的白细胞或白色血细胞。使用新技术，允许可视化针对特定病毒的CTL，我们将定义是什么决定了这些记忆细胞随时间的存活和替换。我们还将确定改变记忆CTL处理体内局部感染的能力的药物。在这样做的过程中，这项工作将提供有价值的见解，可以用来更好地接种疫苗的个人对感染的致病性病毒的方法。