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The anti-oxidative DNA damage protein MTH1, the novel pulmonary hypertension Achilles heel.

The anti-oxidative DNA damage protein MTH1, the novel pulmonary hypertension Achilles heel.
抗氧化 DNA 损伤蛋白 MTH1,是新型肺动脉高压的致命弱点。
批准号:
408074
负责人:
Bonnet Sbastien
金额:
$54.62万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-09-01 至 2024-09-01

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中文摘要
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英文摘要
Patients with pulmonary arterial hypertension have a dysfunction of the cells constituting the wall of their arteries in the lungs. Like cancer cells, PAH cells are characterized by exaggerated capacity to multiplicate and resistance to death resulting in
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Exploring the Interplay between Metabolic and Epigenetic Signalling Pathways to Regulate Neointima Hyperplasia
  • 批准号:
    477700
  • 项目类别:
    Operating Grants
  • 资助金额:
    $81.37万
  • 财政年份:
    2023
  • 负责人:
    Bonnet Sbastien
  • 依托单位:
Targeting Hypusine signaling: an opportunity to counter pulmonary vascular remodelling in pulmonary arterial hypertension
  • 批准号:
    467948
  • 项目类别:
    Operating Grants
  • 资助金额:
    $61.58万
  • 财政年份:
    2022
  • 负责人:
    Bonnet Sbastien
  • 依托单位:
Replication stress and pulmonary hypertension: Role for checkpoint kinase 1
  • 批准号:
    368035
  • 项目类别:
    Operating Grants
  • 资助金额:
    $51.83万
  • 财政年份:
    2017
  • 负责人:
    Bonnet Sbastien
  • 依托单位:
Canada Research Chair Tier 2
  • 批准号:
    333108
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2014
  • 负责人:
    Bonnet Sbastien
  • 依托单位:
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