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Effects of circulating insulin on metabolism and mammalian longevity

Effects of circulating insulin on metabolism and mammalian longevity
循环胰岛素对新陈代谢和哺乳动物寿命的影响
批准号：
254608
负责人：
Johnson James D
金额：
$54.96万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=254608&lang=en
关键词：
Autophagy And Protein Homeostasis Extra-Pancreatic Insulin In The Brain Healthy Aging Hormonal And Neuronal Control Of Longevity Insulin As A Tissue Growth Factor Insulin Resistance And Glucose Homeostasis Knockout Mouse Models Mechanisms Of Aging

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Both genetic and environmental factors are thought to contribute to growth, healthy aging and longevity. Studies in worms and flies have clearly demonstrated that the insulin signaling has a negative effect on longevity. Seemingly counterintuitive evidenc
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