Effects of circulating insulin on metabolism and mammalian longevity

循环胰岛素对新陈代谢和哺乳动物寿命的影响

• 批准号: 254608
• 负责人: Johnson James D
• 金额: $ 54.96万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2017-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=254608&lang=en
• 关键词: Autophagy And Protein Homeostasis; Extra-Pancreatic Insulin In The Brain; Healthy Aging; Hormonal And Neuronal Control Of Longevity; Insulin As A Tissue Growth Factor; Insulin Resistance And Glucose Homeostasis; Knockout Mouse Models; Mechanisms Of Aging

Both genetic and environmental factors are thought to contribute to growth, healthy aging and longevity. Studies in worms and flies have clearly demonstrated that the insulin signaling has a negative effect on longevity. Seemingly counterintuitive evidenc

遗传和环境因素都被认为有助于生长、健康衰老和长寿。对蠕虫和苍蝇的研究清楚地表明，胰岛素信号对寿命有负面影响。看似违反直觉的证据