Beta-cell resilience to insulin-driven stress in type 1 diabetes: Lessons from both sexes

1 型糖尿病中 β 细胞对胰岛素驱动压力的恢复能力：两性的经验教训

• 批准号: 446710
• 负责人: Johnson James D
• 金额: $ 0.73万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=446710&lang=en
• 关键词: Autophagy And Lysosomal Protein Homeostasis; Extracellular Vesicles And Exosomes; Human Islet Studies; Insulin Transcription; Insulin Translation; Molecular Mechanisms Of Type 1 Diabetes; Pancreatic Beta-Cell Biology; Pre-Clinical Genetically Engineered M

Type 1 diabetes (T1D), often diagnosed in children, affects >300,000 Canadians. In T1D, the immune system targets and destroys a special type of cell called a beta cell which makes insulin. It is becoming clear that problems within beta cells and changes

1型糖尿病（T1D），通常在儿童中诊断，影响超过30万加拿大人。在T1D中，免疫系统靶向并破坏一种称为β细胞的特殊类型的细胞，该细胞产生胰岛素。越来越清楚的是，β细胞内的问题和变化