Characterization and Manipulaton of Protein Structure- Function Relationships for Bioprocess Application

生物过程应用中蛋白质结构-功能关系的表征和操作

• 批准号: 8606179
• 负责人: James Bailey
• 金额: $ 31.68万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8606179&HistoricalAwards=false
• 关键词: Characterization; Manipulaton; Protein; Structure; Function

This project will expand the understanding of proteins in bioprocesses where there proteins are subjected to environments much different from their native biological milieu. Careful investigations of the processing properties of an immobilized enzyme or bound antibody sorbent are to be coordinated with probes of the molecular configuration of such a protein. These fundamental structural probes provide a crucial link for understanding the connections among formulation, use conditions, and functional characteristics of immobilized proteins. All of this research will be conducted in an environment which employs mathematical modeling to assist in interpreting and organizing the data.

这个项目将扩大对生物过程中蛋白质的理解 蛋白质所处的环境与 他们的原生生物环境。 仔细调查 固定化酶或结合抗体的加工性能 吸附剂将与分子探针配位， 这种蛋白质的结构。 这些基本的结构探针 提供了一个关键的环节，以了解之间的联系， 配方、使用条件和功能特性 固定化蛋白质 所有这些研究都将在一个 环境，采用数学建模，以协助 解释和组织数据。