Dissertation Improvement Research (Thailand): Circulating Antigens During Trypanosoma lewisi Infections Characterized by Monoclonal Antibody Procedures

论文改进研究（泰国）：以单克隆抗体程序为特征的路易斯锥虫感染期间的循环抗原

• 批准号: 8619405
• 负责人: Donald Dusanic
• 金额: $ 1.18万
• 依托单位: Indiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-15 至 1989-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8619405&HistoricalAwards=false
• 关键词: Dissertation; Improvement; Research; Thailand; Circulating

This proposal requests funds to permit Ms. Varee Prasertsiriroj, Scientist (on leave of absence for study), Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, to pursue, for a period of 12 months, dissertation research in microbiology and immunology, relevant to development of Thailand, under the direction of Dr. Donald G. Dusanic, Professor, Department of Life Sciences, Indiana State University. The purpose of this study is to identify and characterize important parasite antigens circulating in the plasma of rats infected with Trypanosoma lewisi, a protozoan parasite. These circulating antigens may have a role in immunosuppression or immunoprotection. Attempts will be made to (1) purify these antigens by affinity chromatography using monoclonal antibodies., (2) define them physically and biochemically, and (3) determine their roles in immunity. Parasitic protozoa are a major cause of the infectious diseases which affect man and livestock. They play an important role in limiting the social and economic development of many countries, especially in tropical regions. The research will provide an opportunity to study mechanisms of control of parasitic infections and, therefore, will contribute to development of tropical countries such as Thailand. Dr. Dusanic is a highly respected scientist in the field of this proposal, and he has produced an impressive number of well placed graduates, in the United States and abroad, in the field of parasitology. This project is relevant to the objectives of the Science in Developing Countries Program which seeks to increase the level of cooperation between U.S. scientists and engineers and their counterparts in developing countries through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit.

本提案请求资金，允许泰国曼谷玛希隆大学热带医学院微生物学和免疫学系科学家Varee Prasertsiriroj女士在Donald G. Dusanic教授的指导下，进行为期12个月的与泰国发展有关的微生物学和免疫学博士论文研究。印第安纳州立大学生命科学系。本研究的目的是鉴定和表征大鼠感染刘易斯锥虫（一种原生动物寄生虫）血浆中循环的重要寄生虫抗原。这些循环抗原可能具有免疫抑制或免疫保护作用。将尝试(1)用单克隆抗体亲和层析纯化这些抗原。(2)对它们进行物理和生物化学定义；(3)确定它们在免疫中的作用。寄生原生动物是影响人类和牲畜的传染病的主要原因。它们在限制许多国家，特别是热带地区国家的社会和经济发展方面发挥着重要作用。这项研究将提供一个研究寄生虫感染控制机制的机会，因此将有助于泰国等热带国家的发展。杜萨尼奇博士是本提案领域一位备受尊敬的科学家，他在美国和国外的寄生虫学领域培养了数量可观的优秀毕业生。该项目与“发展中国家科学项目”的目标相关，该项目旨在通过科学信息、思想、技能和技术的交流以及在互利问题上的合作，提高美国科学家和工程师与发展中国家同行之间的合作水平。