U.S.-Sweden Cooperative Research: Examining Errors of Biological Information Transmission Concerning the Genetic Code

美国-瑞典合作研究：检查有关遗传密码的生物信息传输错误

• 批准号: 8619632
• 负责人: Jack Parker
• 金额: $ 0.4万
• 依托单位: Southern Illinois University at Carbondale
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-15 至 1988-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8619632&HistoricalAwards=false
• 关键词: U.S.; Sweden; Cooperative; Research; Examining

This award would support research collaboration between Professor Jack M. Parker, Southern Illinois University, Carbondale, and Professor Charles G. Kurland, University of Uppsala, Sweden. They will study errors of biological information transmission concerning the genetic code. Mistakes seem to occur on the ribosome which refer to the amount of energy invested in protein synthesis. The proposed research will attempt to discover the types of errors, their costs or benefits, and the strategies cells have for coping with the errors. Much of the data on missense errors comes from early in vitro work, but it is not clear ________ how these results correlate with the in vivo situation. _______ Professors Parker and Kurland will study the misreading of phenyla-lanine codons in a native message, both in vivo and in vitro. _______ ________ Professor Parker has systematically explored in vivo missense errors in _______ selected proteins and has expertise in gene manipulation. Professor Kurland and his group have developed a refined in vitro system to study ________ errors in protein synthesis, but he has confined his studies to synthetic messages. Combining the approaches of the two researchers is important because it allows a comparison of in vivo and in vitro _______ ________ misreading of a single message. The proposed research should lead to refinements in the interpretations of the data derived from the two experimental methods.

该奖项将支持南伊利诺伊大学卡本代尔分校的 Jack M. Parker 教授和瑞典乌普萨拉大学的 Charles G. Kurland 教授之间的研究合作。 他们将研究有关遗传密码的生物信息传输错误。 核糖体似乎发生了错误，核糖体指的是蛋白质合成中投入的能量。 拟议的研究将试图发现错误的类型、其成本或收益，以及细胞应对错误的策略。 许多关于错义错误的数据来自早期的体外工作，但尚不清楚这些结果如何与体内情况相关。 _______ Parker 和 Kurland 教授将在体内和体外研究本地信息中苯丙氨酸密码子的误读。 _______ ________ Parker 教授系统地探索了 _______ 选定蛋白质的体内错义错误，并拥有基因操作方面的专业知识。 Kurland 教授和他的团队开发了一种精致的体外系统来研究蛋白质合成中的 ________ 错误，但他将他的研究局限于合成信息。 结合两位研究人员的方法很重要，因为它可以比较体内和体外对单个信息的误读。 拟议的研究应该会改进对两种实验方法得出的数据的解释。