Presidential Young Investigator Award/Analytical Chemistry with Microelectrodes.

总统青年研究员奖/微电极分析化学。

• 批准号: 8657193
• 负责人: Andrew Ewing
• 金额: $ 31.2万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1992-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8657193&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Analytical

This project is in the general area of analytical and surface chemistry and in the subfields of electrochemistry and separation science. Three areas of technological and fundamental importance are addressed by this research. In the first area, extremely small microvoltammetric probes will be disigned and characterized and their use for the dynamic in vivo quantification of intracellular neurotransmitters will be evaluated. In a second area, capillary zone electrophoretic and microcolumn open-tubular liquid chromatographic protocols will be developed for the analysis of ultra-small-volume samples. Coupled with newly developed electrochemical detectors, these methods should permit the detection of sub-femtomolar concentrations of redox-active analytes and provide a static quantitative method for neurotransmitter analysis to complement the dynamic approach already described. Thirdly, the unique electrochemical behavior of metallocene-derivatized phosphazenes and phosphazene polymers will be investigated and their potential utility as charge storage media evaluated. This five year continuing grant to The Pennsylvania State University for the support of Professor Ewing as a Presidential Young Investigator is designed to enable his rapid and effective initiation of this broad and innovative research program in chemistry.

这个项目是在一般地区的分析和表面 化学以及电化学和分离的子领域 科学 三个具有技术和根本重要性的领域 都是通过这项研究解决的。 在第一个领域， 将设计和表征小的微伏安探针 以及它们在动态体内定量 将评估细胞内神经递质。 在第二 区域、毛细管区带电泳和微柱开管 液相色谱协议将开发的 超小体积样品的分析。 再加上新的 开发的电化学检测器，这些方法应该允许 氧化还原活性物质的亚飞摩尔浓度的检测 分析物，并提供静态定量方法， 神经递质分析，以补充动态方法 已经描述过了。 第三，独特的电化学行为 聚苯乙烯衍生的磷腈和磷腈聚合物 将被调查和他们的潜在效用作为收费 存储介质评估。 这五年的持续拨款给宾夕法尼亚州 支持尤因教授担任总统 青年调查员的目的是使他的快速和有效的 启动这一广泛和创新的研究计划， 化学.