GOALI: Application of an Innovative Anti-Biofilm Technology for Overcoming Biofouling on Water Purification Membranes

GOALI：应用创新的抗生物膜技术克服水净化膜上的生物污垢

• 批准号: 1264690
• 负责人: Orlando Coronell Nieto
• 金额: $ 32.6万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2018-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1264690&HistoricalAwards=false
• 关键词: GOALI; Application; Innovative; Anti; Biofilm

1264690 Coronell NietoThis project involves an interdisciplinary university-industry partnership between UNC-Chapel Hill and Agile Sciences, Inc. with the objective of: (1) developing innovative reverse osmosis (RO)/nanofiltration (NF) membranes with enhanced anti-biofouling properties, and (b) building a fundamental understanding of how targeted incorporation of small molecules in the structure of RO/NF membranes affects their physico-chemical properties and performance. The anti-biofouling behavior of the proposed membranes is based on the incorporation of 2-aminoimidazole (2AI) into the structure of the polyamide active layer of RO/NF membranes. 2AI molecules are the only small non-toxic organic molecules that have been shown to inhibit biofilm formation for a wide range of bacteria, and to retain their anti-biofouling properties when attached to a surface. The 2AI molecules will be incorporated both throughout the entire membrane active layer (bulk incorporation) and only at the surface (surface incorporation). Once the 2AI molecules are incorporated into the polyamide active layer, the extent and location of incorporation will be varied systematically to build a fundamental understanding of how targeted incorporation of 2AI small molecules in active layers affects the active layer physico-chemical properties and membrane performance. Equipped with this understanding, the PIs will optimize membranes for anti-biofouling activity, fouling/scaling behavior, water flux and salt rejection. The optimization process will use a series of screening performance tests that will evaluate biofilm inhibition in static conditions, anti-biofouling activity under accelerated biofouling conditions during membrane filtration, conservation of anti-biofouling activity upon successive fouling-cleaning cycles, and organic and colloidal fouling and scaling behavior. The tests will use cross-flow membrane systems, bacterial solutions and natural waters provided by treatment plants. In this project the PIs plan to develop the first non-biocidal biofilm-inhibiting membranes that actively interfere with bacterial signaling mechanisms that trigger biofilm formation. Broader impacts. The development of anti-biofouling water filtration membranes based on 2AI molecules will help establish this new chemistry as a viable approach to achieve anti-biofouling behavior. This development will benefit all fields where antibiofouling surfaces are important (e.g., medical implants, fuel cells, food processing, etc.). The fundamental understanding of the effects that membrane modification with small molecules has on membrane physico-chemical properties and performance will serve as valuable information for membrane developers to accelerate development and optimization cycles. The educational and outreach activities in collaboration with the Chapel Hill High School, Institute for the Environment (Chapel Hill, NC), and Elizabeth City State University (NC), a historically black university, will foster and broaden the participation of women and minority students in engineering and sciences and produce water-related educational materials for dissemination to the broader education community. The PI also plans to disseminate information regarding procedures based on time-of-flight secondary ion mass spectrometry (TOF-SIMS), Rutherford backscattering spectrometry (RBS) and X-ray photoelectron spectroscopy (XPS) as useful methods in the study of the structure and properties of RO/NF membrane active layers.

1264690 Coronell Nieto该项目涉及北卡罗来纳大学教堂山分校和敏捷科学公司之间的跨学科大学-行业合作伙伴关系。其目标是：（1）开发具有增强的抗生物污染特性的创新性反渗透（RO）/纳滤（NF）膜，以及（B）建立对RO/NF膜结构中小分子的靶向掺入如何影响其物理化学特性和性能的基本理解。所提出的膜的抗生物污染行为是基于将2-氨基咪唑（2AI）掺入到RO/NF膜的聚酰胺活性层的结构中。2AI分子是唯一的小无毒有机分子，已被证明可以抑制各种细菌的生物膜形成，并在附着于表面时保持其抗生物污染特性。2AI分子将在整个膜活性层中掺入（本体掺入）和仅在表面掺入（表面掺入）。一旦将2AI分子掺入聚酰胺活性层中，掺入的程度和位置将系统地变化，以建立对活性层中2AI小分子的靶向掺入如何影响活性层物理化学性质和膜性能的基本理解。有了这种理解，PI将优化膜的抗生物污染活性，污染/结垢行为，水通量和盐排斥。优化过程将使用一系列筛选性能测试，这些测试将评估静态条件下的生物膜抑制、膜过滤过程中加速生物污染条件下的抗生物污染活性、连续污垢清洁循环后抗生物污染活性的保持以及有机和胶体污垢和结垢行为。测试将使用交叉流膜系统、细菌溶液和处理厂提供的天然沃茨。 在该项目中，PI计划开发第一种非生物杀灭性生物膜抑制膜，该膜积极干扰触发生物膜形成的细菌信号机制。 更广泛的影响。基于2AI分子的抗生物污染水过滤膜的开发将有助于建立这种新的化学方法，作为实现抗生物污染行为的可行方法。这一发展将有益于抗生物污染表面重要的所有领域（例如，医疗植入物、燃料电池、食品加工等）。对小分子膜改性对膜物理化学性质和性能的影响的基本理解将为膜开发人员提供有价值的信息，以加快开发和优化周期。与查佩尔山高中、环境研究所（北卡罗来纳州查佩尔山）和伊丽莎白城州立大学（北卡罗来纳州一所历史悠久的黑人大学）合作开展的教育和外联活动将促进和扩大妇女和少数民族学生对工程和科学的参与，并编写与水有关的教育材料，分发给更广泛的教育界。PI还计划传播有关飞行时间二次离子质谱法（TOF-SIMS）、卢瑟福背散射光谱法（RBS）和X射线光电子能谱法（XPS）的程序的信息，这些方法是研究RO/NF膜活性层结构和性能的有用方法。