About time; a new biology for the mineralocorticoid receptor

关于时间；

• 批准号: DP230103229
• 负责人: A/Prof Morag Young
• 金额: $ 30.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230103229
• 关键词: About; time; new; biology; mineralocorticoid

Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work.

细胞功能的时间控制使生物途径与环境线索相一致，对哺乳动物的最佳健康至关重要。这个项目将阐明激素受体MR如何调节细胞中生物钟的时间保持。我们将把尖端的遗传模型和生物信息学方法与一套独特的研究模型结合在一起，以定义MR和生物钟之间的相互作用及其在心脏正常生物学中的作用。新的数据将大大提高我们对MR和皮质醇在外周组织中昼夜节律时间保持功能的生物学理解，并更清楚地了解我们的心脏细胞如何适应环境昼夜节律干扰因素，如轮班工作。