Fluorinated Ring and Acyclic Compounds of Groups 15 and 16 -Their Syntheses and Reactions

进一步研究含氟化合物的制备和性质具有重要意义，因为分子中一个或多个氟原子或氟化基团的存在对这些材料的化学和物理性质以及生物活性都有显着的影响。用氟取代化合物中的其他原子，往往会大大提高其在水中的抗热降解或分解能力。在将不含氟的聚乙烯与含氟的特氟龙进行比较时，可以看出这些性能上的巨大差异。这项研究将涉及各种含氟氮、硫和磷化合物的合成和表征，以努力改变已知化合物的特性或开发全新的化合物家族，这些化合物可能具有许多用途，例如作为热稳定性和水解性聚合物、植物生长抑制剂、肌肉松弛剂或抗惊厥剂，此外，还可以在同时研究氟化和非氟化类似物时提供许多有用的基本信息。这项研究将为其他研究人员提供有关热力学和动力学稳定性、性质、结构和成键的信息，以及各种类型化合物的合成方法。所有新材料都将通过红外、拉曼、核磁共振、质谱分析和元素分析进行表征。其中许多将被提交进行生物测试，一些将被提交进行结构研究。

Further research on the preparation and properties of fluorine compounds is important because the presence of one or more fluorine atoms or fluorinated groups in molecules has a marked effect on the chemical and physical properties as well as on the biological activity of these materials. The substitution of fluorine for other atoms in a compound often leads to profound increases in resistance to thermal degradation or decomposition in water. These drastic differences in properties are seen in comparing polyethylene, which does not contain fluorine, to teflon, which does contain fluorine. The research will involve the syntheses and characterization of a wide variety of fluorine-containing nitrogen, sulfur and phosphorus compounds in an effort to either modify characteristics of previously known compounds or to develop entirely new families of compounds that may have many applications, e.g., as thermally and hydrolytically stable polymers, as plant growth inhibitors, as muscle relaxants, or as anticonvulsants, in addition to providing much useful basic information when fluorinated and nonfluorinated analogs are studied concurrently. This study will provide other researchers with information about thermodynamic and kinetic stabilities, properties, structures and bonding as well as methods of synthesis of a diverse collection of compound types. All new materials will be characterized via infrared, Raman, nuclear magnetic resonance and mass spectra and elemental analyses. Many will be submitted for biological testing and some for structural studies.