Fluorine-Containing Electrophilic and Nucleophilic Transfer Reagents

这个无机、生物无机和有机金属化学项目的奖项支持爱达荷大学Jean'ne Shreeve教授实验室的研究。Shreeve提出了一种基于简单无机分子的新型单氟烷基和多氟烷基亲电转移剂。该提案清楚地概述了制备这些试剂的各种合成路线。虽然已知各种全氟烷基转移剂，但这些试剂通常需要使用繁琐的合成方法或具有有限的适用范围。期望开发的新试剂具有适用于各种模板分子衍生化、在亲核试剂存在和光解条件下稳定的优点。其他研究将包括从相应的全氟烷基化和多氟烷基化硅烷中进行的全氟烷基和多氟烷基基团的亲核转移。在分子中掺入氟或含氟基团会对母体分子的化学和物理性质产生显著影响。这些变化增加了亲脂性，改善了水解和热稳定性。因此，制药、医疗和聚合物行业对这类化合物的需求持续增长。该计划开发的试剂有望更有效、更经济地生产含氟化合物。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research in the laboratories of Professor Jean'ne Shreeve at the University of Idaho. Shreeve has proposed to develop a new class of per- and poly-fluoroalkyl electrophilic transfer agents based upon simple inorganic molecules. The proposal clearly outlines a variety of synthetic routes for the preparation of these reagents. Although a variety of perfluoroalkyl transfer agents are known, these reagents often require the use of tedious synthetic methodologies or possess a limited scope of applicability. The new reagents to be developed are expected to offer the advantages of being applicable to the derivatization of a variety of template molecules and being stable in the presence of nucleophiles and under photolytic conditions. Additional studies will include the nucleophilic transfer of per- and poly-fluoroalkyl groups from the corresponding per- and poly-fluoroalkylated silanes. The incorporation of fluorine or fluorine-containing groups into molecules has a marked effect upon the chemical and physical properties of the parent molecule. These changes result in increased lipophilicity and improved hydrolytic and thermal stability. As a result, the demand for such compounds by the pharmaceutical, medical and polymer industries continues to grow. The reagents developed in this program are expected to result in the more efficacious and economical production of fluorine-containing compounds.