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Fluorine-Containing Electrophilic and Nucleophilic Transfer Reagents

含氟亲电和亲核转移试剂

基本信息

批准号：
9720635
负责人：
Jean'ne Shreeve
金额：
$ 31.43万
依托单位：
Regents of the University of Idaho
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1998
资助国家：
美国
起止时间：
1998-02-15 至 2002-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9720635&HistoricalAwards=false
关键词：
Fluorine Containing Electrophilic Nucleophilic Transfer

项目摘要

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research in the laboratories of Professor Jean'ne Shreeve at the University of Idaho. Shreeve has proposed to develop a new class of per- and poly-fluoroalkyl electrophilic transfer agents based upon simple inorganic molecules. The proposal clearly outlines a variety of synthetic routes for the preparation of these reagents. Although a variety of perfluoroalkyl transfer agents are known, these reagents often require the use of tedious synthetic methodologies or possess a limited scope of applicability. The new reagents to be developed are expected to offer the advantages of being applicable to the derivatization of a variety of template molecules and being stable in the presence of nucleophiles and under photolytic conditions. Additional studies will include the nucleophilic transfer of per- and poly-fluoroalkyl groups from the corresponding per- and poly-fluoroalkylated silanes. The incorporation of fluorine or fluorine-containing groups into molecules has a marked effect upon the chemical and physical properties of the parent molecule. These changes result in increased lipophilicity and improved hydrolytic and thermal stability. As a result, the demand for such compounds by the pharmaceutical, medical and polymer industries continues to grow. The reagents developed in this program are expected to result in the more efficacious and economical production of fluorine-containing compounds.

该奖项在无机，生物无机和有机化学该计划支持Jean'ne教授实验室的研究爱达荷州大学的施里夫。 Shreeve建议开发一个新型全氟烷基和多氟烷基亲电转移剂基于简单的无机分子。该提案明确提出了一个用于制备这些试剂的多种合成路线。尽管已知多种全氟烷基转移剂，但这些全氟烷基转移剂可用于制备聚硅氧烷。试剂通常需要使用冗长的合成方法适用范围有限。新试剂将预计开发的产品将提供适用于各种模板分子的衍生化，并在亲核试剂的存在下和在光解条件下。额外研究将包括亲核转移的per-and 多氟烷基基团来自相应的全氟烷基和多氟烷基化硅烷。将氟或含氟基团结合到分子对化学和物理性质有显著的影响母体分子。这些变化导致亲脂性增加以及改善的水解和热稳定性。因此，需求制药、医疗和聚合物工业对这些化合物的需求一个继续增长本计划开发的试剂预计从而更有效和经济地生产含氟化合物。