Relaxation Kinetics of Ion Transport Across Biomembranes

跨生物膜离子传输的弛豫动力学

• 批准号: 8703860
• 负责人: T. Dewey
• 金额: $ 19.2万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8703860&HistoricalAwards=false
• 关键词: Relaxation; Kinetics; Ion; Transport; Across

The transport of ions across biological membranes is a fundamental process which is essential to a variety of physiological phenomena. In addition to being critical to the basic metabolism and bioenergetics of most cells, it is key to many other more specific processes. Neurotransmission, muscle action and vision are just a few examples of biological events that are mediated by the transport of ions. A deeper understanding of ion transport could have far reaching consequences in several areas of biochemistry. Dr. Dewey is investigating the transmembrane ion transport kinetics for two of the better characterized transport proteins, bacteriorhodopsin and calcium ATPase. Knowledge of the rates of the individual, elementary reaction steps is required for a detailed, molecular description of an ion transport process. A modulation relaxation kinetic technique developed in his laboratory will be used. This method will provide new information for evaluating reaction mechanisms.

离子穿过生物膜的运输是一种 一个基本的过程，这是必不可少的各种 生理现象。 除了至关重要， 大多数细胞的基本代谢和生物能量学，它是 这是许多其他更具体过程的关键。 神经传递、肌肉动作和视觉只是其中的几个 由细胞因子介导的生物事件的实例 离子的运输。 更深入地了解离子传输 可能会在几个领域产生深远的影响， 生物化学 杜威博士正在研究跨膜离子转运 两种较好表征的运输动力学 蛋白质、细菌视紫红质和钙ATP酶。 知识 单个基元反应步骤的速率为： 需要对离子进行详细的分子描述 运输过程。 一种调制弛豫动力学技术 在他的实验室里开发的。 此方法将 为评价反应机理提供了新的信息。