EAGER: Design and Processing of Anti-microbial Surfaces Using Polymer Extrusion Additive Manufacturing Embedding Silver Nanoparticles with Enhanced Ion Releasing Kinetics

EAGER：使用聚合物挤出增材制造嵌入银纳米粒子并增强离子释放动力学来设计和加工抗菌表面

• 批准号: 2231306
• 负责人: Damon Smith
• 金额: $ 19.69万
• 依托单位: University of New Orleans
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2231306&HistoricalAwards=false
• 关键词: EAGER; Design; Processing; Anti; microbial

Silver nanoparticles are appealing for healthcare applications because of their strong antimicrobial ability against common bacteria and viruses. However, the concentration of nanoparticles needed to manufacture antimicrobial products can be prohibitively costly. Meanwhile, additive manufacturing has shown great potential for the rapid production of biomedical devices and personal protective equipment that desire an antimicrobial function. By incorporating silver nanoparticles into polymer filaments for material extrusion additive manufacturing, the nanoparticle quantity needed for antimicrobial parts may be substantially reduced through controlling processing settings and part geometry, while still maintaining antimicrobial characteristics. This EArly-concept Grants for Exploratory Research (EAGER) award supports fundament research that will gain knowledge on how silver nanoparticles incorporated as well as part geometric and processing conditions may influence ion releasing kinetics and the effectiveness in antimicrobial ability of fabricated parts. The research outcomes may potentially improve the ability to reduce the spread of infection diseases in medical care applications and thus benefit the well-being of the society. This project will also contribute to the education in manufacturing for students from underrepresented groups through the development of a workshop that targets students from Delgado Community College, the largest minority-serving community college in Louisiana. Students attending the workshop will gain exposures to the materials of this project and additional education and research opportunities in advanced manufacturing areas.The objective of this research is to understand how additive manufacturing processing and designs govern the concentration of silver nanoparticles on fabricated surfaces that require antimicrobial properties. The adhesion and growth of bacteria and the release of silver ions that eradicate bacteria depend not only on surface topography but also the internal voids of a part. The novelty of the approach lies upon employing deposition infill patterns, layer heights, and nozzle sizes to produce specimens with (i) surface topography with high tortuosity that limits favorable attachment sites and confines the growth of surface bacteria, and (ii) increased internal voids, while without sacrificing other component performance, for a higher release rate of antimicrobial silver ions at part surfaces. The interdisciplinary research team will test these outcomes by characterization of specimen morphologies, silver ion release rates, and the adhesion and growth of the common bacteria Escherichia coli and Staphylococcus aureus by optical and electron microscopy, mass spectrometry, and antimicrobial assays, respectively. The project will offer a better understanding of how additive manufacturing processing and design parameters influence the antimicrobial mechanisms, which can be used to develop design strategies for a wide range of cost-effective healthcare applications that can be used to limit infection rates.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

银纳米颗粒吸引了医疗保健应用，因为它们对常见细菌和病毒具有强大的抗菌能力。但是，生产抗菌产品所需的纳米颗粒的浓度可能是昂贵的。同时，添加剂制造具有巨大的潜力，可以快速生产想要具有抗菌功能的生物医学设备和个人保护设备。通过将银纳米颗粒掺入聚合物丝中以进行材料挤出添加剂生产，可以通过控制加工设置和部分几何形状来大大减少抗菌部件所需的纳米颗粒数量，同时仍保持抗菌特性。这项早期概念授予探索性研究（急切）奖支持基础研究，这些研究将获得有关如何合并的银纳米颗粒以及零件的​​几何和加工条件的知识，并可能影响释放动力学的离子及其有效性，并在制造零件的抗菌剂能力中的有效性。研究结果可能会提高减少感染疾病在医疗保健应用中的传播的能力，从而使社会福祉受益。该项目还将通过开发一个针对路易斯安那州最大的少数族裔社区学院Delgado社区学院的学生的研讨会来为来自代表性不足的团体的学生的制造教育做出贡献。参加研讨会的学生将获得对该项目材料的曝光，并在高级制造领域的其他教育和研究机会。该研究的目的是了解添加剂制造加工和设计如何控制需要抗菌特性的制造表面上的银纳米颗粒浓度。细菌的粘附和生长以及消除细菌的银离子的释放不仅取决于表面形象，还取决于零件的内部空隙。该方法的新颖性在于采用沉积填充图案，层高和喷嘴​​大小以产生（i）具有高曲折的表面形态的标本，限制了有利的附着位点并限制了表面细菌的生长，并且（ii）增加了内部空隙，同时又不牺牲其他组件，而不是牺牲其他组件，而是牺牲了其他组件，而是抗抗元素的一部分。跨学科研究团队将通过表征标本形态，银离子释放率以及通过光学和电子显微镜，质谱法和抗菌分析​​的普通细菌和金黄色葡萄球菌的粘附和生长来测试这些结果。该项目将更好地理解添加剂制造处理和设计参数如何影响抗菌机制，这些机制可用于为广泛的具有成本效益的医疗保健应用制定设计策略，这些应用可用于限制感染率。该奖项反映了NSF的法定任务，并通过评估基金会的Merit和Broadial and tobleit and toctial and Broadia and Broadia and Broadia and Broadia and Broadia and Broadia and Broadia and Broadia and Broadia and Broadia and Broadia and toblecia and toctial and tobleit。