Sinusoidal voltage protocols for characterisation of ion channel kinetics

用于表征离子通道动力学的正弦电压协议

• 批准号: DP190101758
• 负责人: Dr Adam Hill
• 金额: $ 28.73万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101758
• 关键词: Sinusoidal; voltage; protocols; characterisation; ion

This project aims to implement an innovative approach to modelling ion channel behaviour that employs short, information-rich datasets and parameter inference. Using the hERG potassium channel as a test case, the project will show that this approach is more efficient than current methods and outperforms all published models in independent validations. The project aims to extend on initial implementation to probe the thermodynamics and pharmacology of ion channel gating. The anticipated outcomes are to grow fundamental knowledge of ion channel biophysics and ability to probe ion channel function in silico. The project will build on an emerging collaboration between international leaders in physiology, pharmacology, mathematics and computer modelling. The methodology and fundamental knowledge generated will significantly advance our understanding of the physiology and biophysics of ion channels, while the application of the method will have direct impact in the pharmaceutical industry and regulatory science.

该项目旨在实施一种创新的方法来模拟离子通道行为，该方法采用简短、信息丰富的数据集和参数推理。使用hERG钾通道作为测试用例，该项目将表明该方法比当前方法更有效，并且在独立验证中优于所有已发表的模型。该项目旨在扩展初步实施，以探索离子通道门控的热力学和药理学。预期的结果是增长离子通道生物物理学的基本知识和探测硅离子通道功能的能力。该项目将建立在生理学、药理学、数学和计算机建模领域的国际领导者之间的新兴合作基础上。所产生的方法和基础知识将大大促进我们对离子通道生理学和生物物理学的理解，而该方法的应用将对制药工业和监管科学产生直接影响。