Acquisition of a Mass Spectrometer and Upgrading of FAB-MS Capabilities

购置质谱仪并升级 FAB-MS 功能

• 批准号: 8704142
• 负责人: Frederick Lampe
• 金额: $ 29万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-15 至 1988-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8704142&HistoricalAwards=false
• 关键词: Acquisition; Mass; Spectrometer; Upgrading; FAB

Mass spectral (MS) techniques such as Electron Impact (EI) and Fast Atom Bombardment (FAB) are used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The acquisition of instrumentation capable of carrying out these state-of-the-art techniques is essential for the prosecution of frontier research in several fields of chemistry. The purchase of a new mass spectrometer and the upgrading of FAB-MS capabilities will be facilitated by support from the Chemistry Shared Instrumentation Program and the Biological Instrumentation Program. The major areas of research that will be enhanced include: 1) The chemistry of phosphazenes 2) Glycosation-site analysis of rat alpha-1 acid glycoprotein 3) Chemistry of pterins 4) Capillary zone electrophoresis-mass spectrometry 5) Template controlled oligomerizations 6) Synthetic organometallic chemistry

质谱（MS）技术，例如电子轰击（EI）和 快原子轰击（FAB）用于探测亲密的 结构细节，并获得分子组成 大量的有机的，生物有机的，和有机金属的 分子。 购置能够 执行这些最先进的技术是必不可少的 在若干领域进行前沿研究， 化学. 购买一台新的质谱仪， FAB-MS的能力将得到 化学共享仪器计划和生物 仪表计划。研究的主要领域， 加强的措施包括： 1)磷腈化学 2)大鼠α-1酸的糖基化位点分析 糖蛋白 3)蝶呤化学 4)毛细管区带质谱 5)模板控制的低聚反应 6)合成有机金属化学