RUI: Role of Peptides in Modulating the Output of a Small Neural System
RUI:肽在调节小型神经系统输出中的作用
基本信息
- 批准号:8706568
- 负责人:
- 金额:$ 13.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:1987
- 资助国家:美国
- 起止时间:1987-07-15 至 1990-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In recent years, an enormous number of neurotransmitter and neuromodulatory substances have been identified in both vertebrate and invertebrate substances. These substances include a number of amines and an ever-increasing number of neuropeptides, the exact physiological roles of which are still unclear. However, it appears in many cases that the peptides are modulatory in nature, provoking relatively long-term alterations of ongoing neuronal activity or inducing such activity in previously quiescent preparations. Such modification and modulation of neuronal activity is common to all animals, and is essential to a wide variety of activities. Studies of the roles of neuropeptides in modulating neuronal activities will thus serve to clarify further not only the physiological roles of the many substances found in the nervous system but also the mechanisms by which neuronal modulation can occur. Perhaps the most amenable systems for the study of modulation at present are those systems in which a regularly patterned activity occurs. One such system, in which the role of peptides in modulating neuronal activity can be addressed readily, is the stomatogastric nervous system of decapod crustaceans. Questions related to the peptidergic modulation of neuronal activity, particulary rhythmically patterned activity, have already been approached from several perspectives. Considerable effort has been devoted to identifying and localizing a variety of neuropeptides in the stomatogastric system. In addition, the physiological effects of a number of neuropeptides on the stomatogastric system have been studied. Furthermore, at least one modulatory neuron has been identified, and its modulatory effects on the system have been studied. What is lacking, however, is the synthesis of these three types of experiments, the positive identification of the transmitters used by individual modulatory neurons and the effects of these neurons when fired in a physiologically relevant manner. The present study by Dr. Patsy Dickinson is designed to begin to fill this gap in our knowledge in two ways: (1) by identifying and recording from neurons containing neuropeptides, and (2) by examining modulatory neurons for the presence of these neuropeptides.
近年来,大量的神经递质 神经调节物质已经在这两种细胞中被发现, 脊椎动物和无脊椎动物的物质。 这些物质 包括多种胺和不断增加的 神经肽,其确切的生理作用仍然是 不清楚 然而,在许多情况下, 在本质上是调节性的, 正在进行的神经元活动的改变或诱导这种 在以前静止的制剂中的活性。 等 神经元活动的修饰和调节是常见的, 所有的动物,是必不可少的各种活动。 神经肽在神经元调控中的作用研究 因此,这些活动不仅有助于进一步澄清 在神经系统中发现的许多物质的生理作用 系统,但也机制,神经元调制可以 发生. 也许最适合研究 调制目前是那些系统,其中定期 模式化的活动发生。 一个这样的系统,其中肽在细胞中的作用是 调节神经元活动可以很容易地解决, 甲壳纲十足目动物的口胃神经系统。 与神经元肽能调节相关的问题 活动,特别是有节奏的活动, 已经从几个角度进行了探讨。 已作出相当大的努力, 定位各种神经肽在口胃 系统 此外,一些生理效应 神经肽对口胃系统的影响。 此外,至少一个调节神经元已经被 已确定,其对系统的调节作用已被 研究了 然而,缺乏的是这些因素的综合。 三种类型的实验,阳性鉴定 单个调节神经元使用的神经递质, 当这些神经元在生理上被激发时, 相关的方式。 Patsy Dickinson博士目前的研究是 旨在开始填补这一空白,在我们的知识在两个 方法:(1)通过识别和记录含有 神经肽,和(2)通过检查调节神经元, 这些神经肽的存在。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Patsy Dickinson其他文献
Patsy Dickinson的其他文献
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{{ truncateString('Patsy Dickinson', 18)}}的其他基金
Collaborative Research: RUI: Diversity of modulation and functional flexibility in small neuronal networks: An evolutionary and mechanistic approach
合作研究:RUI:小神经元网络中调制的多样性和功能灵活性:一种进化和机械方法
- 批准号:
1856433 - 财政年份:2019
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
Collaborative Research: RUI: Molecular mechanisms and physiological triggers underlying neuromodulator plasticity in a lobster pattern generator
合作研究:RUI:龙虾模式发生器中神经调节剂可塑性的分子机制和生理触发因素
- 批准号:
1354567 - 财政年份:2014
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
RUI: Coordinated modulation of a multi-layered neuromuscular system
RUI:多层神经肌肉系统的协调调节
- 批准号:
1121973 - 财政年份:2011
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
RUI: The Role of Multiple Modulators in a Small Neural System: A Comparative Approach
RUI:多个调制器在小型神经系统中的作用:比较方法
- 批准号:
0111040 - 财政年份:2001
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
RUI: The Role of Neuromodulators and Their Interactions in Controlling the Output of a Small Neural System
RUI:神经调节剂及其相互作用在控制小型神经系统输出中的作用
- 批准号:
9723885 - 财政年份:1997
- 资助金额:
$ 13.58万 - 项目类别:
Continuing Grant
Addition of Investigative Labs and Modern Data Acquisition to Physiology Labs at All Levels of the Curriculum
在各级课程的生理学实验室中增加研究实验室和现代数据采集
- 批准号:
9751267 - 财政年份:1997
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
RUI: Role of Peptides in Modulating the Output of a Small Neural System
RUI:肽在调节小型神经系统输出中的作用
- 批准号:
9310003 - 财政年份:1993
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
RUI: Role of Peptides in Modulating the Output of a Small Neural System
RUI:肽在调节小型神经系统输出中的作用
- 批准号:
9008816 - 财政年份:1990
- 资助金额:
$ 13.58万 - 项目类别:
Continuing Grant
Neural Control and Modulation of Water Regulatory Behavior
水调节行为的神经控制和调节
- 批准号:
8316961 - 财政年份:1983
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
Neural Control and Modulation of Water Regulatory Behavior
水调节行为的神经控制和调节
- 批准号:
8119270 - 财政年份:1982
- 资助金额:
$ 13.58万 - 项目类别:
Standard Grant
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