Protein Structure and Folding at Low Temperature
Protein Structure and Folding at Low Temperature
批准号:
8716292
负责人:
Anthony Fink
金额:
$25.45万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-04-01 至 1991-09-30
中文摘要
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英文摘要
An understanding of how and why a protein folds into its native conformation is of major biological importance. Although much work has been done on this problem still relatively little is known about the details of the process. Dr. Fink is studying the factors which determine a particular folding pathway and hence native structure. The long-term goals are to learn the "rules" by which the amino acid sequence of a polypeptide guides the folding path to the native state. Dr. Fink will use: 1) specific signals or probes in different regions of the molecule to aid determining the order in which the protein folds and unfolds; 2) site-specific mutants to facilitate the formation of protein with environment-sensitive probes in unique and selected sites and probe the role of individual amino acids on the folding; and 3) subzero temperatures and aqueous-methanol cryosolvents to permit the stabilization and characterization of partially-folded intermediates in both unfolding and refolding.
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会议论文
U.S.-Japan Cooperative Science: Protein Folding at Subzero Temperatures
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批准号:9726633
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项目类别:Standard Grant
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资助金额:$1.41万
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财政年份:1998
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负责人:Anthony Fink
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依托单位:
ATR FTIR Investigation of Beta-Lactamase Catalysis
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批准号:9730035
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项目类别:Continuing Grant
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资助金额:$28.0万
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财政年份:1998
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负责人:Anthony Fink
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依托单位:
FASEB Summer Research Conference on Amyloid and Protein Assembly Processes" to be held at Copper Mountain, Colorado,July 13-18, 1997
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批准号:9722070
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项目类别:Standard Grant
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资助金额:$0.3万
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财政年份:1997
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负责人:Anthony Fink
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依托单位:
Mechanisms of Enzyme Catalysis
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批准号:9418724
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项目类别:Continuing Grant
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资助金额:$27.4万
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财政年份:1995
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负责人:Anthony Fink
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依托单位:
Early Events in Protein Folding
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批准号:9507280
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项目类别:Continuing Grant
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资助金额:$26.94万
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财政年份:1995
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负责人:Anthony Fink
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依托单位:
SCINTILLATION PROXIMITY FLUOROGRAPHY: A NEW METHOD FOR TRACKING BIOMOLECULES IN CELLS
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批准号:9107558
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项目类别:Standard Grant
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资助金额:$12.0万
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财政年份:1991
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负责人:Anthony Fink
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依托单位:
U.S.-Japan Cooperative Research: "Role of Molten Globule State in the Structure and Function of Proteins"
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批准号:9016819
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项目类别:Standard Grant
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资助金额:$0.74万
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财政年份:1991
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负责人:Anthony Fink
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依托单位:
Low Temperature Trapping of Intermediates in Enzyme- Catalyzed Reactions
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批准号:9107070
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项目类别:Continuing Grant
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资助金额:$23.8万
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财政年份:1991
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负责人:Anthony Fink
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依托单位:
Protein Structure and Folding at Low Temperature
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批准号:9019530
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项目类别:Continuing Grant
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资助金额:$26.0万
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财政年份:1991
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负责人:Anthony Fink
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依托单位:
Low Temperature Trapping of Intermediates in Enzyme- Catalyzed Reactions
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批准号:8810144
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项目类别:Continuing Grant
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资助金额:$17.88万
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财政年份:1988
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负责人:Anthony Fink
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依托单位:
Workshop on Protein Folding, February 24,25, and 26, 1984 California
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批准号:8403386
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项目类别:Standard Grant
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资助金额:$0.5万
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财政年份:1984
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负责人:Anthony Fink
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依托单位:
Low Temperature Trapping of Intermediates in Enzyme Catalyzed Reactions
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批准号:8402393
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项目类别:Continuing Grant
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资助金额:$18.0万
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财政年份:1984
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负责人:Anthony Fink
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依托单位:
Protein Structure and Folding at Low Temperature
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批准号:8310472
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项目类别:Continuing Grant
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资助金额:$21.5万
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财政年份:1983
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负责人:Anthony Fink
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依托单位:
Low-Temperature Trapping of Intermediates in Enzyme- Catalyzed Reactions
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批准号:8110073
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项目类别:Continuing Grant
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资助金额:$13.5万
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财政年份:1981
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负责人:Anthony Fink
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依托单位:
Protein Structure and Folding at Low Temperatures
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批准号:7913766
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项目类别:Continuing Grant
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资助金额:$13.28万
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财政年份:1980
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负责人:Anthony Fink
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依托单位:
Construction of a Crystal Microspectrophotometer
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批准号:8003443
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项目类别:Standard Grant
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资助金额:$5.03万
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财政年份:1980
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负责人:Anthony Fink
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依托单位:
Low-Temperature Trapping of Intermediates in Enzyme- Catalyzed Reactions
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批准号:7822892
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项目类别:Continuing Grant
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资助金额:$10.5万
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财政年份:1979
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负责人:Anthony Fink
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依托单位:
Low Temperature Trapping of Intermediates in Enzyme- Catalyzed Reactions
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批准号:7602702
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项目类别:Continuing Grant
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资助金额:$10.4万
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财政年份:1976
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负责人:Anthony Fink
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依托单位:
Low Temperature Trapping of Intermediates in Enzyme- Catalyzed Reactions
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批准号:7205128
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项目类别:Continuing Grant
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资助金额:$2.09万
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财政年份:1973
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负责人:Anthony Fink
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依托单位:
海外基金