Mn(III) Based Oxidative Free Radical Cyclizations (Chemistry)

这项研究得到了有机和 高分子化学计划。 经济社会发展呈现 一种潜在的非常一般的方法， 多环结构 这些在许多复杂的 用于现代医学和农业的分子。 本研究将开发锰（III）基氧化剂 自由基环化成一种可靠和通用的方法 用于合成高度官能化的环状和 多环化合物 研究计划将集中在 以下问题：（1）发起团体的范围;（2） 双键取代模式的类型， 以及内环或外环基团是否 （3）可以形成的环的尺寸;（4） 双键上可容许的官能团;（5） 可以在其他地方被容忍的官能团 分子量;（6）芳构化反应的范围;（7） 添加剂对反应性质的影响;（8） 氧化终止的范围和限制， Mn（0Ac）3·2 H2O和/或Cu（0Ac）2·H2O、LiCl和LiX;和（9）该化合物 形成第二或第三个国家的范围和限制 戒指

This research is being supported by the Organic and Macromolecular Chemistry Program. It will develop the methodology for a potentially very general route into polycyclic structures. These are found in many of the complex molecules used in modern medicine and agriculture. This research will develop the manganese (III) based oxidative free radical cyclization into a reliable and versatile method for the synthesis of highly functionalized cyclic and polycyclic compounds. The research program will focus on the following questions: (1) the scope of initiating groups; (2) the type of double bond substitution patterns that can be tolerated and whether endocyclic or exocyclic radicals are formed; (3) the ring sizes that can be formed; (4) the functional groups that can be tolerated on the double bond; (5) the functional groups that can be tolerated elsewhere in the molecule; (6) the scope of the aromatization reaction; (7) the effect of additives on the nature of the reaction; (8) the scope and limitations of the oxidative termination with Mn(OAc)3.2H2O and/or Cu(OAc)2.H2O, LiCl and LiX; and (9) the scope and limitations for the formation of a second or third ring.