Mathematical Sciences: Problems in Population Genetics

数学科学：群体遗传学问题

• 批准号: 8802039
• 负责人: Stanley Sawyer
• 金额: $ 9.38万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-15 至 1991-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8802039&HistoricalAwards=false
• 关键词: Mathematical; Sciences; Problems; Population; Genetics

Theoretical models and data analysis are to be used to study intragenic recombination in bacteria, as well as other aspects of population dynamics that can be inferred from statistical analysis of DNA sequences. A typical question is (i) attempt to estimate the relative strength of classical genetic drift and gene conversion as conservative forces in equilibrium allele distributions in prokaryotes. Recently developed statistical techniques for analysing DNA sequences have shown strong evidence for common between-strain gene conversion involving segments of 300 base pairs or less in the bacterium Escherichia coli. Other topics proposed are to (ii) study the statistical power and consistency of these tests, (iii) develop statistical techniques for estimating the frequency of this type of intragenic recombination with strains external to a sample.

理论模型和数据分析将被用于研究细菌的基因内重组，以及可以从DNA序列的统计分析中推断的种群动态的其他方面。一个典型的问题是(I)试图估计在原核生物的平衡等位基因分布中，作为保守力的经典遗传漂移和基因转换的相对强度。最近发展起来的用于分析DNA序列的统计技术已经表明，在大肠杆菌中，涉及300个碱基对或更少的片段的菌株之间常见的基因转换是强有力的证据。建议的其他主题是(Ii)研究这些测试的统计能力和一致性，(Iii)开发统计技术，估计这种类型的基因内重组与样本外菌株重组的频率。