Improvement of Recombinant DNA Research Facilities

重组DNA研究设施的改进

• 批准号: 8805151
• 负责人: Graciela Candelas
• 金额: $ 29万
• 依托单位: University of Puerto Rico-Rio Piedras
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-15 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8805151&HistoricalAwards=false
• 关键词: Improvement; Recombinant; DNA; Research; Facilities

The Research Improvement in Minority Institutions (RIMI) program was designed to increase the participation of minorities in scientific and engineering research. The program provides support to strengthen the research environment and capabilities of institutions that have substantial minority student enrollments. Eligible institutions must also have graduate programs in science or programs in engineering. The principal investigators at the University of Puerto Rico (Rio Piedras) will use RIMI support to purchase equipment to upgrade facilities for recombinant DNA technology within the Department of Biology. Small equipment will be provided for equipping individual laboratories while major equipment items will be designated for shared access. These latter acquisitions will result in upgrading self contained facilities which include a dark room, a four-degree centigrade cold room and units employed for DNA sequencing radio immunoassey and chromatography. This support will facilitate ongoing studies in which recombinant DNA methodologies such as the preparation of gene librarea, cloning, hybridization techniques and DNA sequencing are being employed to study mechanisms of gene expression in a wide range of species, including spiders, sea urchins, lizards, birds, yeast and protozoa. These studies address such fundamental problems as the identification and characterization of regulatory genes, the role of small RNA molecules in their interaction with regulatory genes and the role of the DNA in the decoding process. The survival potential of genetically engineered bacteria is yet the subject of another study. This project will clearly meet the objectives of the RIMI program in several ways. It will significantly strengthen the scientific research infrastructure, provide an opportunity for an isolated population of minority students to become well-educated in modern biotechnology and serve to promote cooperative research projects with other institutions including industrial and government laboratories. The principal investigator is an experienced and active minority researcher. She has excellent qualifications for overseeing the development and management of these new facilities as well as to guide and assist young investigators in the application of this technology to their own research. This RIMI project will encourage more minority students to consider research careers in science and engineering.

少数民族机构研究改进（RIMI）计划 旨在增加少数群体参与科学和 工程研究 该方案提供支持，以加强 研究机构的研究环境和能力， 大量少数民族学生入学。 合资格机构必须 也有研究生课程在科学或工程项目。 波多黎各大学（里约）的主要研究人员 Piedras）将利用RIMI支持购买设备进行升级 重组DNA技术的设施， 生物学 将提供小型设备， 实验室，而主要设备项目将被指定为共享 access. 这些收购将导致自我升级 包含的设施，其中包括一个黑暗的房间，四度 用于DNA测序无线电的摄氏度冷藏室和单元 免疫测定和色谱法。 这一支持将促进正在进行的研究，其中重组DNA 如基因文库的制备，克隆， 杂交技术和DNA测序被用来 研究多种物种的基因表达机制， 包括蜘蛛、海胆、蜥蜴、鸟类、酵母和原生动物。 这些研究解决了诸如识别 和表征的调控基因，小RNA的作用， 分子与调控基因的相互作用以及 DNA在解码过程中 的生存潜力 基因工程细菌是另一项研究的主题。 该项目将明确满足RIMI计划的目标， 几种方式。 这将大大加强科学 研究基础设施，为一个孤立的 少数民族学生在现代社会中接受良好教育 生物技术，并促进合作研究项目， 其他机构，包括工业和政府实验室。 主要研究者是一个有经验和积极的少数 研究员 她有很好的资格监督 这些新设施的开发和管理，以及指导 并帮助年轻的研究人员应用这项技术 他们自己的研究。 这个RIMI项目将鼓励更多的少数民族 学生考虑在科学和工程的研究生涯。