Inclusion Chemistry of Flexible Hosts

灵活主体的包合化学

• 批准号: 8807163
• 负责人: Jerry Atwood
• 金额: $ 23.44万
• 依托单位: University of Alabama Tuscaloosa
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8807163&HistoricalAwards=false
• 关键词: Inclusion; Chemistry; Flexible; Hosts

This project in the Inorganic, Bioinorganic and Organometallic Chemistry Program is in the area of host-guest chemistry. The project is directed toward an understanding of the interaction of flexible hosts with a variety of guest molecules. For the hosts, focus will be on liquid clathrates and calixarenes. Fundamental understanding of the ability of guests to organize hosts will be investigated. A comparison of the polarity of the cavity and that of the solvent will be sought for a range of systems. Heavy reliance on single crystal X-ray diffraction, nuclear magnetic resonance spectroscopy and molecular modelling will be necessary to characterize the structures and interactions. The development of flexible hosts as models for clay minerals and for bioinorganic molecules is planned. For the latter, calixarenes will be functionalized using standard synthetic organic procedures. Aminocalixarenes will be synthesized and their complexation of transition metal ions will be investigated. Information derived from studies of flexible hosts will be applied to problems of separation science. This study is expected to provide important fundamental information about interactions between species in solutions and about the kinds of interactions which are involved in the recognition of substrates by enzymes. The study may also lead to new methodology for the separation of mixtures of chemicals.

该项目在无机，生物无机和有机 化学课程是在主-客体化学领域。的 该项目旨在了解 由各种各样的客体分子组成的灵活的主体。为 主持人，重点将放在液体包合物和杯芳烃。 基本了解客人的组织能力 房东将接受调查。的极性的比较， 将在一定范围内寻求空腔和溶剂的空腔， 系统.严重依赖单晶X射线衍射， 核磁共振波谱和分子模拟 将有必要描述结构的特征， 交互.开发柔性主机作为 粘土矿物和生物无机分子的研究正在计划中。为 后者，杯芳烃将使用标准的 合成有机程序。氨基杯芳烃将是 过渡金属离子的合成及其络合作用 将进行调查。资料来源于下列研究： 灵活的主机将应用于分离问题 科学 这项研究将为我们提供重要的基础知识。 关于溶液中物种之间相互作用的信息， 关于参与的各种相互作用 酶对底物的识别这项研究也可能导致 用于分离化学品混合物的新方法。